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A new marker of bone disease, sclerostin, the two pro\u2010inflammatory cytokines tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha) and interleukin\u201018 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018), and the fibroblast growth factor\u201023 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023) receptor\u2010associated marker Klotho were tested in 84 haemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients and in healthy controls. The patients had significantly higher levels of the three former markers than of the controls while Klotho was significantly higher in the controls. Low level, but significant, correlations were observed in the patient group when the levels of these four markers were compared to each other and to those of 5 cytokines and growth factors tested earlier; high\u2010sensitive<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>(hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106), hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>), fibroblast growth factor\u201023 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023) and soluble urokinase plasminogen activator (su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>). Ln sclerostin correlated positively to Ln hs<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha, Ln<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>and Ln su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>. Ln hs<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha correlated positively to Ln sclerostin, Ln hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, Ln<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, Ln<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023, Ln su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>and Ln<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018. Ln<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 correlated positively to Ln su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>and Ln<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha. Ln Klotho correlated negatively to Ln hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>but did not correlate to Ln<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023. The markers studied here may be involved in the calcification of vessels seen in<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>patients due to a combination of inflammation and bone disease. The mechanisms are still not fully known but may be of importance for future therapeutic possibilities in this group of patients.<\/jats:p>","DOI":"10.1111\/sji.12392","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T17:22:46Z","timestamp":1444324966000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sclerostin,<scp>TNF<\/scp>\u2010alpha and Interleukin\u201018 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients"],"prefix":"10.1111","volume":"83","author":[{"given":"G.","family":"Almroth","sequence":"first","affiliation":[{"name":"Department of Nephrology Institution of medicine and health sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00f6nn","sequence":"additional","affiliation":[{"name":"Division of Clinical 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