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In this study, we investigate the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 on bile duct ligation\u2010induced liver injury and fibrosis in C57BL\/6 mice. Animals were sacrificed at designated times, and serum and liver tissues were collected for analysis of liver function and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and transforming growth factor\u2010\u03b2 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2) levels. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 blockade with anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A mAb significantly improved liver function and decreased hepatocellular necrosis, pro\u2010inflammatory cytokines, neutrophils and macrophages influx. Furthermore, CD3\u00a0+\u00a0and CD8\u00a0+\u00a0lymphocytes, neutrophils and macrophages were found to express IL\u201017, and neutrophils are the principal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010producing cells after <jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content>\u2010induced liver injury. These data indicated that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 signal contributes to the pathogenesis of cholestatic liver injury and blocked of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 could potentially benefit patients with cholestatic liver disease.<\/jats:p>","DOI":"10.1111\/sji.12395","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T20:33:35Z","timestamp":1445373215000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Neutralization of Interleukin\u201017 Attenuates Cholestatic Liver Fibrosis in Mice"],"prefix":"10.1111","volume":"83","author":[{"given":"S.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery Guangzhou First People's Hospital Guangzhou Medical University Guangzhou Digestive Disease Center Guangzhou 510180 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