{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:41:40Z","timestamp":1792413700340,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["n\u00b0602699 DIREKT"],"award-info":[{"award-number":["n\u00b0602699 DIREKT"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 22q11.2 deletion syndrome (22q11.2 <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:4000 births. These patients may suffer from affection of many organ systems with cardiac malformations, thymic hypoplasia or aplasia, hypoparathyroidism, palate anomalies and psychiatric disorders being the most frequent. The incidence of autoimmune diseases is increased in older patients. The aim of the present study was to examine a cytokine profile in patients with 22q11.2 <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> by measuring a broad spectrum of serum cytokines. Patients with a proven deletion of chromosome 22q11.2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) and healthy individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a054) recruited from an age\u2010 and sex\u2010comparable group were included in the study. Serum levels of 27 cytokines, including chemokines and growth factors, were analysed using multiplex technology. Interferon\u2010inducible protein 10 (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010) was also measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> to confirm the multiplex results. The 22q11.2 <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> patients had distinctly and significantly raised levels of pro\u2010inflammatory and angiostatic chemokine <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared to controls. The patients with congenital heart defects (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) had significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) raised serum levels of <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 compared to patients born without heart defects (<jats:italic>n<\/jats:italic>\u00a0=\u00a024). The other cytokines investigated were either not detectable or did not differ between patients and controls.<\/jats:p>","DOI":"10.1111\/sji.12406","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T03:58:38Z","timestamp":1451275118000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased Levels of Interferon\u2010Inducible Protein 10 (<scp>IP<\/scp>\u201010) in 22q11.2 Deletion Syndrome"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-4702","authenticated-orcid":false,"given":"D. M.","family":"Aresvik","sequence":"first","affiliation":[{"name":"Department of Pediatric Research Women and Children's Division Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Medicine Akershus University Hospital L\u00f8renskog Norway"},{"name":"Department of Pediatrics, Women and Children's Division Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"\u00d8verland","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Children's Division Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Mollnes","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Oslo Norway"},{"name":"University of Oslo Oslo Norway"},{"name":"Research Laboratory Nordland Hospital Bod\u00f8 Norway"},{"name":"K.G. Jebsen TREC University of Troms\u00f8 Troms\u00f8 Norway"},{"name":"Center of Molecular Inflammation Research Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Children's Division Oslo University Hospital Oslo Norway"},{"name":"University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.9.789-a"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00322"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182060469"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.030619"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1161-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.333"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.01.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0842-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200412000-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.12.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.04.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03038.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2273011499"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.12.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/434010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00047.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.3.246"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02007-13"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1206"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0879-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000209968.66606.10"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.1.155"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012700"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.04.002"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm819"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032429"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833cf3bc"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.04.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.11.010"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70200-2"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:11:55Z","timestamp":1696151515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/sji.12406"],"URL":"https:\/\/doi.org\/10.1111\/sji.12406","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"2015-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}