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The <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> genotypes were determined by the polymerase chain reaction\u2013ligase detection reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content>) analysis in 330 <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> patients and 608 unrelated cancer\u2010free\u00a0controls. In this case<jats:italic>\u2013<\/jats:italic>control study, there was no significant difference in the\u00a0genotype and allele distributions of four <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> polymorphisms between <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> patients and controls. However, haplotype association analysis indicated\u00a0that compared with <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> G<jats:sub>rs733618<\/jats:sub>C<jats:sub>rs16840252<\/jats:sub>G<jats:sub>rs231775<\/jats:sub>C<jats:sub>rs3087243<\/jats:sub>, <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> G<jats:sub>rs733618<\/jats:sub>C<jats:sub>rs16840252<\/jats:sub>A<jats:sub>rs231775<\/jats:sub>G<jats:sub>rs3087243<\/jats:sub> and A<jats:sub>rs733618<\/jats:sub>C<jats:sub>rs16840252<\/jats:sub>G<jats:sub>rs231775<\/jats:sub>A<jats:sub>rs3087243<\/jats:sub> haplotypes conferred increased risks of <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.46, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.33\u201331.28; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.012; both); however, <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> A<jats:sub>rs733618<\/jats:sub>C<jats:sub>rs16840252<\/jats:sub>A<jats:sub>rs231775<\/jats:sub>G<jats:sub>rs3087243<\/jats:sub> and A<jats:sub>rs733618<\/jats:sub>T<jats:sub>rs16840252<\/jats:sub>G<jats:sub>rs231775<\/jats:sub>G<jats:sub>rs3087243<\/jats:sub> haplotypes conferred decreased risks of <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011, respectively). These results highlight that the rare <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>4<\/jats:italic> haplotypes may affect the development of <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> in the Chinese population.<\/jats:p>","DOI":"10.1111\/sji.12409","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T04:08:44Z","timestamp":1451275724000},"page":"212-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Investigation of <i>Cytotoxic T\u2010lymphocyte antigen 4<\/i> Polymorphisms in Gastric Cardia Adenocarcinoma"],"prefix":"10.1111","volume":"83","author":[{"given":"W.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The Union Clinical Medical College of Fujian Medical University Fuzhou Fujian 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