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To gain an insight into the changes of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and FcRn expression after immunodeficiency virus (<jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SIV<\/jats:styled-content>) infection, real\u2010time <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> methods were established and the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and FcRn in normal and <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SIV<\/jats:styled-content>\u2010infected rhesus macaques were quantitatively examined. It was found that the levels of <jats:styled-content style=\"fixed-case\">pIgR mRNA<\/jats:styled-content> were within a range of 10<jats:sup>7<\/jats:sup> copies per million copies of <jats:styled-content style=\"fixed-case\">GAPDH mRNA<\/jats:styled-content> in the gut mucosa of rhesus macaques, which were up to 55 times higher than that in the oral mucosa, the highest among the non\u2010gut tissues examined. Levels of FcRn <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> were generally lower than that of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content>, and the levels of FcRn <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in the gut mucosa were also lower than that in most non\u2010gut tissues examined. Notably, the levels of <jats:styled-content style=\"fixed-case\">pIgR mRNA<\/jats:styled-content> in the duodenal mucosa were positively correlated with that of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in normal rhesus macaques. Both <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and FcRn <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels were significantly reduced in the duodenal mucosa during acute <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content> infection and in the jejunum and caecum during chronic <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SIV<\/jats:styled-content> infection. These data expanded our knowledge on the expression of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and FcRn in the gastrointestinal tract of rhesus macaques and demonstrated altered expression of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and FcRn in <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SIV<\/jats:styled-content>, and by extension <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infections, which might have contributed to HIV\/AIDS pathogenesis.<\/jats:p>","DOI":"10.1111\/sji.12416","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T10:47:20Z","timestamp":1455101240000},"page":"235-243","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Alteration of Polymeric Immunoglobulin Receptor and Neonatal Fc Receptor Expression in the Gut Mucosa of Immunodeficiency Virus\u2010Infected Rhesus Macaques"],"prefix":"10.1111","volume":"83","author":[{"given":"Y.","family":"Wang","sequence":"first","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Beijing China"},{"name":"Dalian Center for Disease Control and Prevention Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GB.","family":"Yang","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.37"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.915"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01424-12"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242543"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.54.23"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.12938\/bmfh.31.51"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00341-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.4008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2004.20.972"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2155"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0160-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801717105"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150718"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00326.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1212-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12529"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003776"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05441-11"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13612"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1074\/jbc.C300470200","article-title":"Engineered human IgG antibodies with longer serum half\u2010lives in primates","volume":"20","author":"Hinton PR","year":"2004","journal-title":"J Biol Chem"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.07.007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200955"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.98"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1464-y"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3209-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.041061-0"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.10.008"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmp.12054"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"12490","DOI":"10.1016\/S0021-9258(18)43301-7","article-title":"The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. 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