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However, the application of such approach in the potential antigen discovery of autoimmune diseases remains largely unexplored. Here, we describe a previously uncharacterized region, with disease\u2010associated autoantigens, to build antigen networks with three bioinformatics tools, namely NetworkAnalyst, Gene<jats:styled-content style=\"fixed-case\">MANIA<\/jats:styled-content> and ToppGene. First, we identified histone H2<jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content> as an antigen of systemic lupus erythematosus by comparing highly ranked genes from all the built network\u2010derived gene lists, and then a new potential biomarker for Behcet's disease, heat shock protein <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> 90\u2010alpha (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>90<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>1), was further screened out. Moreover, 130 confirmed patients were enrolled and a corresponding enzyme\u2010linked immunosorbent assay, mass spectrum analysis and immunoprecipitation were performed to further confirm the bioinformatics results with real\u2010world clinical samples in succession. Our findings demonstrate that the combination of multiple molecular network approaches is a promising tool to discover new immune targets in diseases.<\/jats:p>","DOI":"10.1111\/sji.12452","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T09:24:08Z","timestamp":1464254648000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioinformatics\u2010Driven New Immune Target Discovery in Disease"],"prefix":"10.1111","volume":"84","author":[{"given":"C.","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 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