{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:23:58Z","timestamp":1790004238767,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31230026"],"award-info":[{"award-number":["31230026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81321063"],"award-info":[{"award-number":["81321063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471960"],"award-info":[{"award-number":["81471960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402840"],"award-info":[{"award-number":["81402840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20130495"],"award-info":[{"award-number":["BK20130495"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The commonly used Bacillus Calmette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) vaccine only induces moderate T cell responses and is less effective in protecting against pulmonary tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) in adults and ageing populations. Thus, developing new <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine candidates is an important strategy against the spread of <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. Here, we demonstrated that immunization with heat\u2010shock protein gp96 as an adjuvant led to a significantly increased CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cell response to a <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccine. Secretion of the Th1\u2010type cytokines was increased by splenocytes from gp96\u2010immunized mice. In addition, adding gp96 as an adjuvant effectively improved the protection against intravenous challenge with <jats:italic>Mycobacterium bovis <\/jats:italic><jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> in mice. Our study reveals the novel property of gp96 in boosting the vaccine\u2010specific T cell response and its potential use as an adjuvant for <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccines against mycobacterial infection.<\/jats:p>","DOI":"10.1111\/sji.12463","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T07:31:24Z","timestamp":1468567884000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Heat\u2010Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette\u2010Gu\u00e9rin Vaccine"],"prefix":"10.1111","volume":"84","author":[{"given":"Y.","family":"Ding","sequence":"first","affiliation":[{"name":"College of Life Science and Technology Heilongjiang Bayi Agricultural University Daqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zheng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Feng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Heilongjiang Bayi Agricultural University Daqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Global Tuberculosis Report \u2013 2014","author":"Organization W H","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2014.10.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12274"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502206"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.10.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08525"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004099"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.11.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.061"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1040955"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902368"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300827"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308180101"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30505.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00311.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00321.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.12.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200425200"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.309526"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1524"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27332"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.03.045"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202655"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2010.12.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939593"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02500-14"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.056283-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250480397"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.11.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu347"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.08.033"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00034-08"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.042"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.07.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201061"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3358"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040433"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01240.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01947"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12276"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:25:28Z","timestamp":1696015528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/sji.12463"],"URL":"https:\/\/doi.org\/10.1111\/sji.12463","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]},"assertion":[{"value":"2016-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}