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Thus, developing vaccines to prevent active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> disease remains a priority. This article discusses recent progress in the development of new vaccines against <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> and focusses on the main requirements for development of improved vaccines against <jats:italic>Mycobacterium tuberculosis (M.\u00a0tb)<\/jats:italic>. Over the last two decades, significant progress has been made in <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine development, and some <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine candidates have currently completed a phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> clinical trial. The potential public health benefits of these vaccines are possible, but it will need much more effort, including new global governance investment on this research. This investment would certainly be less than the annual global financial toll of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1111\/sji.12465","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T14:56:38Z","timestamp":1469458598000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Global Efforts in the Development of Vaccines for Tuberculosis: Requirements for Improved Vaccines Against <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1111","volume":"84","author":[{"given":"P.","family":"M\u00e9ndez\u2010Samperio","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas IPN CD M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO(2014)Global Tuberculosis Report 2014. 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