{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:53:01Z","timestamp":1776707581912,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to perform a meta\u2010analysis of eligible studies and to derive a precise estimate of the association between interleukin 10 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10) polymorphisms and susceptibility to autoimmune thyroid disease (<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>). Meta\u2010analyses were conducted on the associations between <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> and the \u20101082 G\/A (rs1800896), \u2010819 C\/T (rs1800871) and \u2010592 C\/A (rs1800872) polymorphisms in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10, and the haplotype of these polymorphisms and <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>. A total of 2903 <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> patients and 3060 controls in 10 eligible studies were included in the meta\u2010analysis. This meta\u2010analysis showed significant associations between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 at the \u20101082 G allele and overall <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.44, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20131.82, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), but no association between the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 \u2010592 C allele and the \u2010819 C allele and <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>. Subgroup studies demonstrated significant associations between the \u20101082 G allele and susceptibility to Graves\u2019 disease. Ethnicity\u2010specific meta\u2010analysis revealed significant associations between the \u20101082 G allele and <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> susceptibility in Asian populations; however, in Middle Eastern populations, no association was evident. Meta\u2010analysis of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 haplotype revealed an association between the <jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content> haplotype and <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.00\u20131.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Meta\u2010analysis demonstrates that the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 polymorphisms are associated with susceptibility to <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12470","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T19:08:14Z","timestamp":1470683294000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta\u2010Analysis"],"prefix":"10.1111","volume":"84","author":[{"given":"J. H.","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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