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Studies indicate that Th1 cytokines reduce fibrosis in schistosomiasis, while Th2 cytokines play a part in the progression of fibrosis, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 has a critical role in this process. The <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013R\u03b12 receptor, known as a \u2018receptor antagonist\u2019 binds with high affinity to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013, and studies have identified that this plays a part in reducing fibrosis and the size of granulomas. The objective of this study was to evaluate the function of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013R\u03b12 and cellular immune response in hepatic fibrosis. A negative correlation between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013R\u03b12 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 was found, suggesting an increase in cytokine in early fibrosis. Initially, a negative correlation between <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 was found in patients without fibrosis, and subsequently, this correlation was found to be positive in patients with severe fibrosis, thereby highlighting a new mechanism for regulating the progress of periportal fibrosis. There was a positive correlation between the profiles of Th1 and Th2 cytokines, suggesting the presence of both responses, thus regulating the disease. The results contribute to a better understanding of the immune mechanisms that control the process of hepatic fibrogenesis in schistosomiasis in humans.<\/jats:p>","DOI":"10.1111\/sji.12472","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T09:13:03Z","timestamp":1470820383000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Receptor Antagonist of <scp>IL<\/scp>\u201013 Exerts a Potential Negative Regulation During Early Infection of Human Schistosomiasis"],"prefix":"10.1111","volume":"84","author":[{"given":"A. L. C.","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Aggeu Magalh\u00e3es Research Center Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L. 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