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The aim was to examine whether this clinical impact of AndoSan<jats:sup>\u2122<\/jats:sup> intake could be explained by influence on foremost pro\u2010inflammatory cytokines in the patients. Fifty patients with symptomatic <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> were randomized and blinded for oral daily intake of AndoSan<jats:sup>\u2122<\/jats:sup> or placebo. Blood samples taken before (visit 1) and after 21\u00a0days\u2019 (visit 3) consumption were analysed for cytokines <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u00df<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012\u201013, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101<jats:italic>\u00df<\/jats:italic> and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>. Baseline cytokine levels were similar in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, cytokine levels at visit 1 versus visit 3 were unaltered within the AndoSan<jats:sup>\u2122<\/jats:sup> and the placebo groups. Only <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 was significantly reduced at visit 3 in the Andosan<jats:sup>\u2122<\/jats:sup> compared with the placebo group. However, when combining <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u00df<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> in the patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, the cytokine levels were significantly lower in the AndoSan<jats:sup>TM<\/jats:sup> \u2010 versus the placebo group, visit 3. In <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>, levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 and <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101<jats:italic>\u00df<\/jats:italic> were reduced within the AndoSan<jats:sup>\u2122<\/jats:sup> group. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 was also reduced at visit 3 compared with placebo. Generally, the effect on reduction in systemic cytokine levels by consumption of AndoSan<jats:sup>\u2122<\/jats:sup> was limited and supported only marginally anti\u2010inflammatory effects in these patients. Therefore, other explanations behind the clinical anti\u2010inflammatory effects than the contribution of cytokines seem more pertinent, including anti\u2010allergic and antioxidant activities.<\/jats:p>","DOI":"10.1111\/sji.12476","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T15:09:34Z","timestamp":1472828974000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cytokine Levels After Consumption of a Medicinal <i>Agaricus blazei<\/i> Murill\u2010Based Mushroom Extract, AndoSan<sup>\u2122<\/sup>, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single\u2010Blinded Placebo\u2010Controlled Study"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-0403","authenticated-orcid":false,"given":"S. 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