{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:24:30Z","timestamp":1791890670198,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Abstract<\/jats:title>Chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) is a common respiratory condition involving the airways and characterized by airflow limitation. Gaseous and noxious particles play an important role in this process. Antioxidants are the substances that may protect cells from the damage caused by unstable molecules known as free radicals. The increased oxidative stress in patients with COPD<\/jats:styled-content> is the result of an increased burden of inhaled oxidants, as well as increased amounts of reactive oxygen species (ROS<\/jats:styled-content>) generated by various inflammatory, immune and epithelial cells of the airways. A total of 150 subjects with COPD<\/jats:styled-content> and 100 healthy controls subjects were enrolled in this study from the period October 2015 to January 2016. The investigation included measurements of plasma superoxide dismutase activity (SOD<\/jats:styled-content>), catalase activity (CAT<\/jats:styled-content>), glutathione content (GSH<\/jats:styled-content>) reduced form, (GP<\/jats:styled-content>x) glutathione peroxidase, glutathione reductase (GR<\/jats:styled-content>) and lipid peroxidation (LPO<\/jats:styled-content>). Absorbance was measured by UV<\/jats:styled-content> spectrophotometer. The estimated values of SOD<\/jats:styled-content>, catalase, GP<\/jats:styled-content>x, GSH<\/jats:styled-content> and GR<\/jats:styled-content> were found to be significantly (P<\/jats:italic>\u00a0=\u00a00.0001) lower among the cases compared with controls. But, the levels of MDA<\/jats:styled-content> were higher (P<\/jats:italic>\u00a0=\u00a00.0001) in cases as compared to control group and there was significant difference in the oxidative stress parameters among the various stages of COPD<\/jats:styled-content>. The post hoc analysis revealed that SOD<\/jats:styled-content> was significantly (P<\/jats:italic>\u00a0<\u00a00.01) lower among the mild, moderate and severe patients compared with very severe patients. The catalase was also observed to be significantly (P<\/jats:italic>\u00a0=\u00a00.01) lower among mild, moderate and severe patients than very severe patients. The GP<\/jats:styled-content>x was found to be significantly (P<\/jats:italic>\u00a0=\u00a00.002) lower among the mild, moderate and severe patients compared with very severe patients. MDA<\/jats:styled-content> was observed to be significantly higher in mild, moderate and severe patients compared with very severe (P<\/jats:italic>\u00a0=\u00a00.001). GR<\/jats:styled-content> was significantly (P<\/jats:italic>\u00a0=\u00a00.003) lower among mild, moderate and severe patients than very severe patients. However, there was no significant difference in GSH<\/jats:styled-content> among severity of COPD<\/jats:styled-content> patients. This study suggests that oxidant and antioxidant imbalance plays an important role in various stages of severity of COPD<\/jats:styled-content>. These results revealed the presence of an oxidative stress in subjects with COPD<\/jats:styled-content>, and it is proportionate to the severity of disease.<\/jats:p>","DOI":"10.1111\/sji.12498","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T03:50:20Z","timestamp":1488513020000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Evaluation of Oxidative Stress and Antioxidant Status in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1111","volume":"85","author":[{"given":"S.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine King George's Medical University Lucknow 226003 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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