{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T21:59:27Z","timestamp":1722290367632},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Fc\u03b3 receptor IIIA (Fc\u03b3RIIIA) has traditionally been known as a positive regulator of immune responses. Consistent with this, mice deficient in Fc\u03b3RIIIA are protected from various inflammation\u2010associated pathologies including several autoimmune diseases. In contrast to this accepted dogma, we show here that mice lacking Fc\u03b3RIIIA developed increased rather than reduced both humoral and cellular immune responses to mucosal (sublingual) immunization with ovalbumin (OVA) given together with the strong mucosal adjuvant cholera toxin as well as to parenteral (subcutaneous) immunization with OVA in complete Freund's adjuvant. After either route of immunization, in comparison with concomitantly immunized wild\u2010type mice, Fc\u03b3RIIIA<jats:sup>\u2212\/\u2212<\/jats:sup> mice had increased serum anti\u2010OVA IgG (IgG1 but not IgG2) antibody responses as well as augmented cellular responses that included memory B cells and effector T cells. The increments in immune responses in Fc\u03b3RIIIA<jats:sup>\u2212\/\u2212<\/jats:sup> mice were similar to those seen in Fc\u03b3RIIB<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Furthermore, OVA\u2010pulsed Fc\u03b3RIIIA<jats:sup>\u2212\/\u2212<\/jats:sup> DCs, similar to OVA\u2010specific Fc\u03b3RIIB<jats:sup>\u2212\/\u2212<\/jats:sup> DCs, had enhanced capacity to activate OVA\u2010specific OT\u2010II T cells, which was even further pronounced when DCs were pulsed with IgG1\u2010complexed OVA. Our data support an inhibitory\u2013regulatory role of Fc\u03b3RIIIA on vaccine\/adjuvant\u2010induced immune responses and demonstrate that lack of Fc\u03b3RIIIA can promote rather than suppress both humoral and cellular immune responses.<\/jats:p>","DOI":"10.1111\/sji.12528","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T13:07:33Z","timestamp":1485522453000},"page":"264-271","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and Adjuvants"],"prefix":"10.1111","volume":"85","author":[{"given":"J.\u2010B.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and University of Gothenburg Vaccine Research Institute (GUVAX) Institute of Biomedicine Sahlgrenska Academy at University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Holmgren","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and University of Gothenburg Vaccine Research Institute (GUVAX) Institute of Biomedicine Sahlgrenska Academy at University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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