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Although vaccination studies in permissive animals took off seven decades ago, the exact mechanisms driving protective immunity are extensively being investigated. Currently, little is known regarding the collective functions or counter\u2010regulatory mechanisms of the antibody isotypes in filarial infection with respect to protective immunity. Establishing the functional role of antibody isotypes and cytokines in the various infection phenotypes can contribute immensely to current knowledge in filarial immunology. This paper reviews insight into protective immunity in filarial infection with focus on humoral and cellular responses from animal models and human studies.<\/jats:p>","DOI":"10.1111\/sji.12533","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T07:47:02Z","timestamp":1486453622000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Immunity in Filarial Infections: Lessons from Animal Models and Human Studies"],"prefix":"10.1111","volume":"85","author":[{"given":"A.","family":"Kwarteng","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Kwame Nkrumah University of Science Technology, PMB Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR) KNUST, PMB Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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