{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:50:30Z","timestamp":1787946630045,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["11115\u2010569\u201034430"],"award-info":[{"award-number":["11115\u2010569\u201034430"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Common variable immunodeficiency (<jats:styled-content style=\"fixed-case\">CVID<\/jats:styled-content>) is a syndrome with predominantly defective B cell function. However, abnormalities in the number and function of other lymphocyte subpopulations in peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) have been described in most patients. We have analysed the distribution of <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cell subpopulations in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">CVID<\/jats:styled-content> patients and the ability of these cells to provide <jats:italic>in\u00a0vitro<\/jats:italic> cognate B cell help. The total of iNKT cells was reduced in the PB of CVID patients, especially CD4+, CD4\u2010\/CD8\u2010 and CCR5+\/CXCR3+. These findings were associated with an enrichment of memory\u2010like and a tendency towards a reduction in <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010expressing effector <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cells in the peripheral blood mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">CVID<\/jats:styled-content> patients. Moreover, an accumulation of follicular helper <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cells in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">CVID<\/jats:styled-content> patients was demonstrated. <jats:styled-content style=\"fixed-case\">CVID <\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>GalCer\u2010pulsed <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cells are not able to induce autologous B cell proliferation although they do induce proliferation to healthy donor B cells. Interestingly, autologous and heterologous co\u2010cultures did not differ in the amount of immunoglobulin secreted by B cells <jats:italic>in\u00a0vitro<\/jats:italic>. Finally, reduced intracellular <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> expression in <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cells and other lymphocytes in the blood from <jats:styled-content style=\"fixed-case\">CVID<\/jats:styled-content> patients was observed. These results provide further insights into the immunological mechanisms underlying the <jats:styled-content style=\"fixed-case\">iNKT<\/jats:styled-content> cell defects and the potential targets to improve B cell help in CVID.<\/jats:p>","DOI":"10.1111\/sji.12576","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T18:27:37Z","timestamp":1497983257000},"page":"171-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Skewed Invariant Natural Killer T (<scp>iNKT<\/scp>) Cells, Impaired <scp>iNKT<\/scp>:B Cell Help and Decreased <scp>SAP<\/scp> Expression in Blood Lymphocytes from Patients with Common Variable Immunodeficiency"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-5609","authenticated-orcid":false,"given":"L. V.","family":"Erazo\u2010Borr\u00e1s","sequence":"first","affiliation":[{"name":"Grupo de Inmunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"\u00c1lvarez\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Grupo de Inmunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Perez\u2010Romero","sequence":"additional","affiliation":[{"name":"Grupo de Inmunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Orrego\u2010Arango","sequence":"additional","affiliation":[{"name":"Grupo de Inmunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Franco\u2010Restrepo","sequence":"additional","affiliation":[{"name":"Grupo de Inmunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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