{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:05:26Z","timestamp":1761609926362,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) is an immune\u2010mediated connective tissue disease of which the aetiology is still unclear. Previous genetic studies including candidate\u2010gene studies and genomewide association studies have identified a number of genetic variations that confer risk to <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. However, these variants, such as single nucleotide polymorphisms, cannot completely explain the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c susceptibility and the diversity in the clinical symptoms of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. The contribution of epigenetic mechanisms as a link between genetics and environmental triggers represents promising field in understanding the pathogenesis of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. The aim of this review was to present the current knowledge on epigenetic mechanisms and highlight novel directions in diagnostic and therapeutical approaches.<\/jats:p>","DOI":"10.1111\/sji.12595","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T10:49:01Z","timestamp":1503312541000},"page":"427-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epigenetics: The Future Direction in Systemic Sclerosis"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-1830","authenticated-orcid":false,"given":"M.","family":"Walczyk","sequence":"first","affiliation":[{"name":"Department of Connective Tissue Diseases National Institute of Geriatrics, Rheumatology and Rehabilitation Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Paradowska\u2010Gorycka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology National Institute of Geriatrics, Rheumatology and Rehabilitation Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Olesinska","sequence":"additional","affiliation":[{"name":"Department of Connective Tissue Diseases National Institute of Geriatrics, Rheumatology and Rehabilitation Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,19]]},"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:17:13Z","timestamp":1696688233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,19]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/sji.12595"],"URL":"https:\/\/doi.org\/10.1111\/sji.12595","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"type":"print","value":"0300-9475"},{"type":"electronic","value":"1365-3083"}],"subject":[],"published":{"date-parts":[[2017,9,19]]},"assertion":[{"value":"2017-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}