{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:13:37Z","timestamp":1781597617910,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Galectin\u20103 has been suggested as a pro\u2010inflammatory mediator in animal arthritis and rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). We aimed to study the serum level of galectin\u20103 in patients with newly diagnosed <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and associations with disease profile, Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) findings and seromarkers of synovial matrix inflammation. One hundred and sixty <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content> na\u00efve patients newly diagnosed with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> were included (<jats:styled-content style=\"fixed-case\">CIMESTRA<\/jats:styled-content> study). Clinical, serological and imaging data were recorded before treatment and at 6\u00a0weeks, 3 and 12\u00a0months. Galectin\u20103 and hyaluronan (<jats:styled-content style=\"fixed-case\">HYA<\/jats:styled-content>) were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> (R&amp;D and Corgenix, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>), and the N\u2010terminal propeptide of type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> collagen (<jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content>) by radioimmunoassay (Orion Diagnostica, Finland). One hundred and nineteen, 87 and 60 blood donors served as controls for galectin\u20103, <jats:styled-content style=\"fixed-case\">HYA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content>, respectively. Baseline galectin\u20103 was significantly elevated in anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> positive (4.2\u00a0<jats:italic>\u03bc<\/jats:italic>g\/l <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> [3.6;6.1]) patients as compared with anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> negatives (4.0\u00a0<jats:italic>\u03bc<\/jats:italic>g\/l [2.6;4.9], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and controls (3.8\u00a0<jats:italic>\u03bc<\/jats:italic>g\/l [3.0;4.8], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). During treatment, galectin\u20103 remained elevated, but increased transiently with peak values at 6\u00a0weeks. Galectin\u20103 correlated with baseline smoking, anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>, and with <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> erosion score after 1\u00a0year of follow\u2010up. <jats:styled-content style=\"fixed-case\">HYA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content> were elevated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) irrespective of anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> status and correlated positively with synovitis assessed clinically and by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HYA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content> did not correlate with galectin\u20103. These observations indicate that <jats:styled-content style=\"fixed-case\">HYA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content> mainly reflect expansive synovitis proliferation while galectin\u20103 is more closely linked to autoimmunity, smoking and joint destructive processes.<\/jats:p>","DOI":"10.1111\/sji.12619","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T08:40:39Z","timestamp":1507538439000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Galectin\u20103 is Persistently Increased in Early Rheumatoid Arthritis (<scp>RA<\/scp>) and Associates with Anti\u2010<scp>CCP<\/scp> Seropositivity and <scp>MRI<\/scp> Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity"],"prefix":"10.1111","volume":"86","author":[{"given":"S. F.","family":"Issa","sequence":"first","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Lindegaard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Hetland","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research Center for Rheumatology and Spine Diseases Rigshospitalet, Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"H\u00f8rslev\u2010Petersen","sequence":"additional","affiliation":[{"name":"Research Unit at King Christian X Hospital for Rheumatic Diseases Graasten Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stengaard\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Ejbjerg","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Slagelse Hospital Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lottenburger","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Junker","sequence":"additional","affiliation":[{"name":"The Institute of Molecular Medicine, Cancer and Inflammation University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Svendsen","sequence":"additional","affiliation":[{"name":"The Danish Twin Registry, Epidemiology Institute of Public Health Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Tarp","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research Center for Rheumatology and Spine Diseases Rigshospitalet, Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Junker","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014233"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110421"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39751"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.12.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.05.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201121m"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwu086"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11287"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1282-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30118"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24574"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.218370"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.2.116"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.1.47"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1203::AID-ART9>3.0.CO;2-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21796"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076307"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.088245"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.125534"},{"key":"e_1_2_8_23_1","first-page":"S44","article-title":"The CIMESTRA study: intra\u2010articular glucocorticosteroids and synthetic DMARDs in a treat\u2010to\u2010target strategy in early rheumatoid arhtritis","volume":"30","author":"Hetland ML","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_24_1","first-page":"1385","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA\u2010MRI scoring system","volume":"30","author":"Ostergaard M","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.149377"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131088"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.05.190"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2016.02.029"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr408"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.09.001"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:16:57Z","timestamp":1696688217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/sji.12619"],"URL":"https:\/\/doi.org\/10.1111\/sji.12619","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}