{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:38:05Z","timestamp":1783471085983,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470946"],"award-info":[{"award-number":["81470946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>This study (1) analysed the percentage of \u03b3\u03b4 T cells, \u03b3\u03b4 T cell subsets, Th17 cells and regulatory T cells (Treg cells) and (2) determined the role of IL<\/jats:styled-content>\u201023 in primary nephrotic syndrome (PNS<\/jats:styled-content>) patients with active disease and in remission. Eighty\u2010four patients with PNS<\/jats:styled-content> and 51 healthy age\u2010matched controls were included in this study. The percentage of \u03b3\u03b4 T cells, \u03b3\u03b4 T cell subsets, Th17 cells and Treg cells in peripheral blood mononuclear cells (PBMC<\/jats:styled-content>s) were analysed by fluorescence\u2010activated cell sorting. PMBC<\/jats:styled-content>s from PNS<\/jats:styled-content> patients with active disease were cultured in the presence of IL<\/jats:styled-content>\u201023, IL<\/jats:styled-content>\u201023 and an IL<\/jats:styled-content>\u201023 antagonist, or IL<\/jats:styled-content>23 and an anti\u2010IL<\/jats:styled-content>\u201021 monoclonal antibody (mA<\/jats:styled-content>b). The percentage of \u03b3\u03b4 T cells, IL<\/jats:styled-content>\u201023R+<\/jats:sup> \u03b3\u03b4 T cells and IL<\/jats:styled-content>\u201017+<\/jats:sup> \u03b3\u03b4 T cells were significantly increased in PNS<\/jats:styled-content> patients with active disease. There was a positive correlation between the percentage of \u03b3\u03b4 T cells, IL<\/jats:styled-content>\u201023R+<\/jats:sup> \u03b3\u03b4 T cells, IL<\/jats:styled-content>\u201017+<\/jats:sup> \u03b3\u03b4 T cells and the Th17\/Treg ratio. IL<\/jats:styled-content>\u201023 increased the percentage of \u03b3\u03b4 T cells and Th17 cells and decreased the percentage of Treg cells in PBMC<\/jats:styled-content>s isolated from PNS<\/jats:styled-content> patients with active disease. Anti\u2010IL<\/jats:styled-content>\u201021 mA<\/jats:styled-content>b reduced the percentage of \u03b3\u03b4 T cells and Th17 cells, but increased the percentage of Treg cells. \u03b3\u03b4 T cells, IL<\/jats:styled-content>\u201017+<\/jats:sup> \u03b3\u03b4 T cells and IL<\/jats:styled-content>\u201023R+<\/jats:sup> \u03b3\u03b4 T cells may be involved in the pathogenesis of paediatric PNS<\/jats:styled-content> by modulating the balance of Th17\/Treg cells. \u03b3\u03b4 T cells may cause an imbalance in Th17\/Treg cells by secreting IL<\/jats:styled-content>\u201021 in the presence of IL<\/jats:styled-content>\u201023.<\/jats:p>","DOI":"10.1111\/sji.12629","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T07:46:38Z","timestamp":1510213598000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["IL<\/scp>\u201023 Activated \u03b3\u03b4 T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL<\/scp>\u201021 in Children with Primary Nephrotic Syndrome"],"prefix":"10.1111","volume":"87","author":[{"given":"L.","family":"Zhang","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yan","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephroimmunology Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephroimmunology Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"},{"name":"The Central Laboratory of Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-9376","authenticated-orcid":false,"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephroimmunology Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephroimmunology Children's Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"724","article-title":"Analysis of 1268 patients with chronic renal failure in childhood: a report from 91 hospitals in China from 1990 to 2002","volume":"42","author":"Yang JY","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006121346"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91880-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350161"},{"key":"e_1_2_7_6_1","first-page":"713","article-title":"T\u2010cell dysfunction in minimal\u2010change nephrotic syndrome of childhood","volume":"136","author":"Fodor P","year":"1982","journal-title":"Am J Dis Child"},{"key":"e_1_2_7_7_1","first-page":"581","article-title":"Evaluation of T lymphocyte subpopulations in children with nephrotic syndrome","volume":"52","author":"Herrod HG","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-010-0330-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021500"},{"key":"e_1_2_7_10_1","first-page":"495","article-title":"Direct presentation of nonpeptide prenyl pyrophosphate antigens to human \u03b3\u03b4 T cells","volume":"3","author":"Morita CT","year":"1996","journal-title":"Microbes Infect"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2001.1850"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"e1005201","DOI":"10.1371\/journal.ppat.1005201","article-title":"Peripheral V\u03b39V\u03b42 T cells are a novel reservoir of latent HIV infection","volume":"11","author":"Sorianosarabia N","year":"2015","journal-title":"PLoS Pathog"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0629-8"},{"key":"e_1_2_7_16_1","first-page":"175","article-title":"Coordinate expansion of \u201cfetal type\u201d lymphocytes (TCR \u03b3\u03b4 T and CD5+ B) in rheumatoid arthritis and primary Sjogren'S syndrome","volume":"77","author":"Brennan F","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00263.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010040"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000038"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01149.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324780"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1252-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.21"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5152\/eajm.2014.36","article-title":"Trace elements in children suffering from idiopathic nephrotic syndrome","volume":"46","author":"Tulpar S","year":"2014","journal-title":"Eurasian J Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80760-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1194-x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.02.018"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032454"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03292.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5948"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1688"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00201.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/art.34327","article-title":"Interleukin\u201021 modulates Th1 and Th17 responses in giant cell arteritis","volume":"64","author":"Terrier B","year":"2012","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_7_36_1","first-page":"3188","article-title":"Interleukin\u201021 is associated with the severity of psoriasis vulgaris through promoting CD4+ T cells to differentiate into Th17 cells","volume":"8","author":"Wang Y","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cupe.2005.04.009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388546"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:27:03Z","timestamp":1695572823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/sji.12629"],"URL":"https:\/\/doi.org\/10.1111\/sji.12629","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"assertion":[{"value":"2017-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}