{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:02Z","timestamp":1787016002332,"version":"build-2736575974"},"reference-count":90,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771090"],"award-info":[{"award-number":["81771090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aberrant expression of interleukin\u201017 (IL\u201017) has been reported in primary Sj\u00f6gren's syndrome (pSS). Abnormalities in IL\u201017 can promote the production of pro\u2010inflammatory cytokines and aggravate autoimmune disorders. The aim of this study was to investigate alterations of IL\u201017 in patients with pSS and explore the correlation between IL\u201017 and disease severity. Eight databases were searched for original studies reporting the expression of IL\u201017 in patients with pSS and controls. Eligible reports were included in the pooled analysis, and subgroup evaluations were performed according to different types of controls and IL\u201017 measurement methods. Newcastle\u2010Ottawa Scale criteria were used to assess the risk of bias of the included studies. In total, 45 articles are included in the meta\u2010analysis. The expression of IL\u201017 is significantly increased in patients with pSS compared to controls. Furthermore, patients with pSS without immunosuppressive treatment show markedly higher IL\u201017 levels. In addition, patients with pSS with positive rheumatoid factors tend to express a higher level of IL\u201017 than patients with negative rheumatoid factors. Negative correlations between IL\u201017 levels and ocular parameters are also found in patients with pSS. The results are similar after adjustment by \u201ctrim and fill\u201d methods. In conclusion, the expression of IL\u201017 is obviously increased in patients with pSS, especially among those without immunosuppressive treatment. In addition, IL\u201017 level correlates with the disease severity of pSS. These findings demonstrate the significance of IL\u201017 overexpression in patients with pSS and may provide insights for the development of therapeutic interventions targeting IL\u201017 for pSS.<\/jats:p>","DOI":"10.1111\/sji.12649","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T02:13:18Z","timestamp":1519438398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Expression of interleukin\u201017 in primary Sj\u00f6gren's syndrome and the correlation with disease severity: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-7989","authenticated-orcid":false,"given":"L.\u2010W.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010R.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University Health Science Center Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University Health Science Center Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S132751"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.17718"},{"key":"e_1_2_7_4_1","article-title":"Cytokines as therapeutic targets in primary Sjogren syndrome","author":"Retamozo S","year":"2017","journal-title":"Pharmacol Ther"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2008.02185.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-017-0174-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22968"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003766"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.05.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12224"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.03.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.09.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.07.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-518167"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2898"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23214"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.06.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090319"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204584"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202500"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12370"},{"key":"e_1_2_7_26_1","unstructured":"WellsG SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses 2011.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. 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