{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:40:05Z","timestamp":1778589605570,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional allergic rhinitis (AR) treatments have limitations due to the lack of safety and complete cure strategy. We evaluated the effects of silent information regulator 1 (SIRT1), a multifunctional molecule involved in a variety of inflammatory pathways, on murine AR model. Ovalbumin (OVA)\u2010induced murine model was constructed, and recombinant SIRT1 was administered into the nostril continuously. The expression of SIRT1 was measured at mRNA and protein levels, and the allergic symptoms were evaluated. Protein levels of OVA\u2010specific IgE, leukotriene C4 (LTC4), eosinophil cation protein (ECP), prostaglandin D2 (PGD2), as well as different inflammatory cytokine mediators in the serum and nasal lavage fluid (NLF), were assessed by ELISA. The effects of SIRT1 on human primary nasal epithelial cells challenged with tumour necrosis factor (TNF)\u2010\u03b1 were also evaluated by investigating the HMGB1\/TLR4 signalling pathway. Administration of SIRT1 significantly alleviated OVA\u2010induced AR symptoms with lower numbers of sneezing and nasal rubbing events, decreased levels of OVA\u2010specific IgE, LTC4, ECP, PGD2, less inflammatory cells and downregulated levels of Th2 type cytokines. SIRT1 also reduced the genes of HMGB1\/TLR4 signalling pathway in the murine model and cultured human nasal epithelial cells. Expression of SIRT1 is impaired in OVA\u2010induced AR model. The administration of SIRT1 alleviates the allergic symptoms of mice, regulates the production of pro\u2010inflammatory mediators predominantly produced by Th2 cells in AR and attenuates expressions of proteins relevant to HMGB1\/TLR4 signalling pathway. All the results showed that SIRT1 is promising as a therapeutic agent of AR.<\/jats:p>","DOI":"10.1111\/sji.12667","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T14:07:07Z","timestamp":1524838027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1\/TLR4 pathway"],"prefix":"10.1111","volume":"87","author":[{"given":"Y.","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Qingdao Municipal Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Qingdao Municipal Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Out\u2010patient Qingdao Municipal Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Qingdao Municipal Hospital (Eastern Campus) Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-9479","authenticated-orcid":false,"given":"J.","family":"Sun","sequence":"additional","affiliation":[{"name":"International Clinic Qingdao Municipal Hospital (Eastern Campus) Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.3.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.053"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101493"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12558"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2012.11.066"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.196790"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00657-10"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00417.2009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-013-9484-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3150"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.11.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0094-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.443"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.03.048"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2258"},{"key":"e_1_2_7_23_1","first-page":"235","article-title":"Correlation of gammadelta\u2010T\u2010cells, Th17 cells and IL\u201017 in peripheral blood of patients with allergic rhinitis","volume":"32","author":"Xuekun H","year":"2014","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4300"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.05.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2531"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00401.2005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12408"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15971"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00274.2014"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:15:06Z","timestamp":1695503706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/sji.12667"],"URL":"https:\/\/doi.org\/10.1111\/sji.12667","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]},"assertion":[{"value":"2018-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12667"}}