{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:37:22Z","timestamp":1763415442836,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R117\u2010A2898\u2010B553","R115\u2010A2764\u2010B553"],"award-info":[{"award-number":["R117\u2010A2898\u2010B553","R115\u2010A2764\u2010B553"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007110","name":"Schering-Plough","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Rationale<\/jats:title>Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA<\/jats:styled-content>). Most studies investigate only 25OHD<\/jats:styled-content> and not the physiologically active vitamin D metabolite, 1,25(OH<\/jats:styled-content>)2<\/jats:sub>D.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment na\u00efve early RA<\/jats:styled-content> patients. Serum level of vitamin D metabolites (25OHD<\/jats:styled-content>2<\/jats:sub>, 25OHD<\/jats:styled-content>3<\/jats:sub> and 1,25(OH<\/jats:styled-content>)2<\/jats:sub>D) was measured by isotope dilution mass spectrometry and radio\u2010immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content>, HAQ<\/jats:styled-content>, VAS<\/jats:styled-content>\u2010scores, CRP<\/jats:styled-content>, erosive status (Total Sharp Score; TSS<\/jats:styled-content>), ACPA<\/jats:styled-content> and IgM\u2010RF<\/jats:styled-content>\u2010status. Associations were evaluated using Spearman's and Wilcoxon rank\u2010sum tests. The study was registered in clinical trials; trial registration number: NCT<\/jats:styled-content>00209859.<\/jats:p><\/jats:sec>Findings<\/jats:title>Statistically significant inverse associations were found between the active metabolite 1,25(OH<\/jats:styled-content>)2<\/jats:sub>D and DAS<\/jats:styled-content>28\u2010CRP<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.004, rho\u00a0=\u00a0\u22120.23), HAQ<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.005, rho\u00a0=\u00a0\u22120.22), CRP<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.001, rho\u00a0=\u00a0\u22120.25), VAS<\/jats:styled-content>patient\u2010pain<\/jats:sub> (P<\/jats:italic>\u00a0=\u00a00.008, rho\u00a0=\u00a0\u22120.21), and a positive association was found to ACPA<\/jats:styled-content>\u2010status (P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The vitamin D metabolite 1,25(OH<\/jats:styled-content>)2<\/jats:sub>D was inversely associated with disease activity and positively associated with ACPA<\/jats:styled-content> in treatment na\u00efve and inflammatory active early RA<\/jats:styled-content>. The results indicate that in RA<\/jats:styled-content>, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect\u2014or might be affected by the level of vitamin 1,25(OH<\/jats:styled-content>)2<\/jats:sub>D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sji.12704","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T11:18:15Z","timestamp":1532085495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The D\u2010vitamin metabolite 1,25(OH<\/scp>)2<\/sub>D in serum is associated with disease activity and Anti\u2010Citrullinated Protein Antibodies in active and treatment na\u00efve, early Rheumatoid Arthritis Patients"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-0850","authenticated-orcid":false,"given":"Mette","family":"Herly","sequence":"first","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Faculty of Health Sciences University of Southern Denmark Odense Denmark"},{"name":"Diagnostic Centre Silkeborg Region Hospital Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0779-8054","authenticated-orcid":false,"given":"Kristian","family":"Stengaard\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Centre of Cancer and Inflammation Aarhus University Hospital Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Departments of Clinical Medicine and Endocrinology Steno Diabetes Center North Jutland Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-467X","authenticated-orcid":false,"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and DANBIO Copenhagen Center for Arthritis Research (COPECARE) Center for Rheumatology and Spine Diseases Glostrup Hospital Rigshospitalet Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-9964","authenticated-orcid":false,"given":"Peter","family":"Junker","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Faculty of Health Sciences University of Southern Denmark Odense 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