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Currently, Bacillus Calmette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) remains the only <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine licensed for human use. This <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine is effective in protecting children against severe military <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> but offers variable protective efficacy in adults. Therefore, new vaccines against <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> are needed to overcome this serious disease. At present, around 14 <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine candidates are in different phases of clinical trials. These <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccines in clinical evaluation can be classified into two groups including preventive pre\u2010 and post\u2010exposure vaccines: subunit vaccines (attenuated viral vectors or adjuvanted fusion proteins), and whole\u2010cell vaccines (genetically attenuated <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>M.\u00a0tb<\/jats:italic>), recombinant <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>, killed <jats:italic>M.\u00a0tb<\/jats:italic> or <jats:italic>M.\u00a0vaccae<\/jats:italic>). Although, over the last two decades a great progress in the search for a more effective <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine has been demonstrated there is still no replacement for the licensed <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccine. This article summarizes the current status of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine development and identifies crucial gaps of research for the development of an effective <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> vaccine in all age groups.<\/jats:p>","DOI":"10.1111\/sji.12710","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T22:47:21Z","timestamp":1535496441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Development of tuberculosis vaccines in clinical trials: Current status"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-914X","authenticated-orcid":false,"given":"Patricia","family":"M\u00e9ndez\u2010Samperio","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas, IPN M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global tuberculosis report 2017. 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