{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:42:30Z","timestamp":1784025750910,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["93\u201004\u201030\u201027699"],"award-info":[{"award-number":["93\u201004\u201030\u201027699"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>All stages of the inflammatory process involved in T cell\u2010mediated chronic skin disorders like psoriasis are affected by redox imbalance. On the other hand, Th17 cells have a critical role in the pathogenesis of psoriasis. In this study, we evaluated redox status in memory<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 + T cells and plasma of patients with psoriasis and its correlation with<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 response. To this end, memory T cells were isolated from 10 patients with psoriasis and 10 controls. Intracellular Glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>), reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) and superoxide as well as<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 were measured using flow cytometry. Plasma total anti\u2010oxidant capacity (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) was quantified by ferric reducing ability of plasma (<jats:styled-content style=\"fixed-case\">FRAP<\/jats:styled-content>) assay. The expression of catalase (<jats:italic><jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content><\/jats:italic>)<jats:italic>,<\/jats:italic>superoxide dismutase 1(<jats:italic><jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1<\/jats:italic>), superoxide dismutase 2<jats:italic>(<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>2<\/jats:italic>), nuclear factor, erythroid 2 like 2 (<jats:italic><jats:styled-content style=\"fixed-case\">NFE<\/jats:styled-content>2L2<\/jats:italic>) and cytochrome b\u2010245 beta chain (<jats:italic><jats:styled-content style=\"fixed-case\">CYBB<\/jats:styled-content>)<\/jats:italic>genes were analysed using real\u2010time<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Our results showed an increased intracellular<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>production in memory<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 + T cells of patients compared to controls<jats:italic>,<\/jats:italic>(<jats:italic>P<\/jats:italic>= 0.04). Furthermore, a significant decrease in expression of catalase gene was found in patients, (<jats:italic>P<\/jats:italic>= 0.02). However, no significant differences were observed for intracellular<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>levels between patients and controls. Also, no correlation was seen between the intracellular<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 level and intracellular<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>and catalase gene expression levels. Collectively, we found an increased<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>production in stimulated memory T cells of patients that could be due to reduced expression of catalase gene. However, it seems that these redox abnormalities have no relationship with<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 response in memory T cells.<\/jats:p>","DOI":"10.1111\/sji.12730","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T10:23:29Z","timestamp":1540895009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Redox imbalance and<scp>IL<\/scp>\u201017 responses in memory<scp>CD<\/scp>4<sup>+<\/sup>T cells from patients with psoriasis"],"prefix":"10.1111","volume":"89","author":[{"given":"Behnaz","family":"Esmaeili","sequence":"first","affiliation":[{"name":"Immunology Department School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Immunology, Asthma and Allergy Research Institute (IAARI) Tehran University of Medical Sciences Tehran 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