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Twelve patients with paired frozen PBMCs before and after 6\u2010month abatacept treatment were included in this sub\u2010study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real\u2010life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment\u2010specific changes. We therefore conclude that studies of patient cohorts displaying wide clinical heterogeneity using mass cytometry must be relatively large in order to be suited for discovery research and immune monitoring. Still, we did find some correlations with functional muscle outcome, namely positive correlations between the ratio of CD4<jats:sup>+<\/jats:sup> T cells and CD8<jats:sup>+<\/jats:sup> T cells (CD4\/CD8) in peripheral blood samples both at baseline and after treatment with muscle endurance improvement as assessed by the functional index\u20102 (FI\u20102) test. Our data suggest that the CD4\/CD8 ratio in circulation at time of active disease may be a predictor of treatment efficacy in myositis patients.<\/jats:p>","DOI":"10.1111\/sji.12732","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T14:57:43Z","timestamp":1542639463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of CTLA4\u2010Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-577X","authenticated-orcid":false,"given":"Quan","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Karolinska University Hospital Solna, Karolinska Institutet, Stockholm 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