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However, it is not clear if the initial clinical, microbiological or immunological characteristics are impacting the worse response to treatment. This study aimed to identify the predictive value of clinical, microbiological and immunological patterns on the clinical response to therapy in GAgP patients. Twenty\u2010four GAgP patients were selected, and gingival crevicular fluid (GCF) and subgingival biofilm were collected. <jats:italic>Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> levels were evaluated by qPCR, and IL\u20101\u03b2 and IL\u201010 concentration by ELISA. Twelve patients were treated with SRP (scaling and root planning), and twelve with SRP plus 375\u00a0mg amoxicillin and 250\u00a0mg metronidazole (8\/8\u00a0hours, 7\u00a0days) (SRP\u00a0+\u00a0AM). The clinical changes (Probing Pocket Depth [PPD] reduction and Clinical Attachment Level [CAL] gain) 6\u00a0months post\u2010treatment were correlated to the initial clinical, inflammatory and microbiological variables using stepwise logistic regression (\u03b1\u00a0=\u00a05%). CAL gain at 6\u00a0months was 1.16\u00a0\u00b1\u00a00.77 for SRP and 1.74\u00a0\u00b1\u00a00.57\u00a0mm for SRP\u00a0+\u00a0AM (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). PPD reduction was 1.96\u00a0\u00b1\u00a00.82 for SRP and 2.45\u00a0\u00b1\u00a00.77\u00a0mm for SRP\u00a0+\u00a0AM (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). In the SRP group, IL\u201010 showed a predictive value for clinical response. The higher the IL\u201010 concentration at baseline, the higher the reduction in PPD at 6\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.68). However, when antimicrobials were administered, no significant influence was detected (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). It can be concluded that the IL\u201010 levels in GFC act as a predictor of clinical response to GAgP. Moreover, the intake of antimicrobials appears to overlap the influence of the inflammatory response on clinical response to treatment.<\/jats:p><jats:p>Clinical trial registration number: NCT03933501.<\/jats:p>","DOI":"10.1111\/sji.12816","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T10:55:24Z","timestamp":1566816924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Local IL\u201010 level as a predictive factor in generalized aggressive periodontitis treatment response"],"prefix":"10.1111","volume":"90","author":[{"given":"Tiago","family":"Taiete","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontics Periodontics Division Piracicaba Dental School University of Campinas Piracicaba SP Brazil"},{"name":"Department of Dentistry University of Araras Araras  SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-4349","authenticated-orcid":false,"given":"Mabelle F.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Periodontics Division Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Z.","family":"Casati","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Periodontics Division Piracicaba Dental School University of Campinas Piracicaba SP Brazil"},{"name":"Department of Periodontics Paulista University S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Felipe","family":"do Vale","sequence":"additional","affiliation":[{"name":"Department of Periodontics Amazonas State University Manaus Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia M. B.","family":"Ambosano","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Piracicaba Dental School State University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco H.","family":"Nociti","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Periodontics Division Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson A.","family":"Sallum","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Periodontics Division Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato C. 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