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While pathological lesions are limited to the central nervous system (CNS), disease\u2010specific proteins accumulate and replicate in secondary lymphoid organs prior to neuroinvasion, and their replication there depends on the abundance of cellular prion protein (PrP<jats:sup>C<\/jats:sup>). PrP<jats:sup>C<\/jats:sup> is expressed in both central and peripheral lymphoid tissues, and up\u2010 or downregulates innate and adaptive immune responses. In addition to prion diseases, PrP<jats:sup>C<\/jats:sup> is also immunologically involved in other neurological disorders and infectious diseases, including Alzheimer's disease and human immunodeficiency virus infection. Herein, we summarize the expression and functions of PrP<jats:sup>C<\/jats:sup> in various immunocytes, as well as its immunological and pathological roles in neurodegeneration and infection.<\/jats:p>","DOI":"10.1111\/sji.12854","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:18:37Z","timestamp":1575281917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Expression and functions of cellular prion proteins in immunocytes"],"prefix":"10.1111","volume":"91","author":[{"given":"Baizhuo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Neuroscience Centre The First Hospital of Jilin University Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Centre The First Hospital of Jilin 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