{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:40:54Z","timestamp":1790185254485,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1808085QH245"],"award-info":[{"award-number":["1808085QH245"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the effect of long non\u2010coding RNA XLOC_003810 on the activation of CD4<jats:sup>+<\/jats:sup> T cells and expression of PD\u20101\/PD\u2010L1 in patients with myasthenia gravis\u2010related thymoma (MG\u2010T). Thymus specimens and thymic mononuclear cells were obtained from MG and MG\u2010T patients or cardiac surgery patients undergoing thoracotomy who were selected as negative controls (NC). XLOC_003810 expression was examined using quantitative real\u2010time PCR (qRT\u2010PCR). Frequency of CD4<jats:sup>+<\/jats:sup> T cells and proportion of CD4<jats:sup>+<\/jats:sup>PD\u20101<jats:sup>+<\/jats:sup> T cells and CD14<jats:sup>+<\/jats:sup>PD\u2010L1<jats:sup>+<\/jats:sup> monocytes were quantified by flow cytometry. The release of inflammatory cytokines was measured by qRT\u2010PCR and enzyme\u2010linked immunosorbent assay. Compared with the NC group, expression of XLOC_003810, frequency of CD4<jats:sup>+<\/jats:sup> T cells and the production of inflammatory cytokines were increased in patients with MG and MG\u2010T. XLOC_003810 overexpression significantly increased the frequency of CD4<jats:sup>+<\/jats:sup> T cells, facilitated the production of inflammatory cytokines and decreased the proportion of CD4<jats:sup>+<\/jats:sup>PD\u20101<jats:sup>+<\/jats:sup> T cells and CD14<jats:sup>+<\/jats:sup>PD\u2010L1<jats:sup>+<\/jats:sup> monocytes in the thymic mononuclear cells. In contrast, XLOC_003810 knockdown exerted the opposite effect. Together, XLOC_003810 promotes T cell activation and inhibits PD\u20101\/PD\u2010L1 pathway in patients with MG\u2010T.<\/jats:p>","DOI":"10.1111\/sji.12886","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T17:36:11Z","timestamp":1585935371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["LncRNA XLOC_003810 promotes T cell activation and inhibits PD\u20101\/PD\u2010L1 expression in patients with myasthenia gravis\u2010related thymoma"],"prefix":"10.1111","volume":"92","author":[{"given":"Bo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Anhui Medical University Hefei 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