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Together with B cells, respective self\u2010reactive T cells have an important contribution in disease progression as being responsible for inflammatory cytokines secretion, B cell activation and promoting amplification of the autoimmune response. Annexin A1 is expressed by many cell types and binds to phospholipids in a Ca<jats:sup>2+<\/jats:sup>\u2010dependent manner. Abnormal expression of annexin A1 was found on activated B and T cells in both murine and human autoimmunity suggesting its potential role as a therapeutic target. In the present study, we have investigated the possibility to suppress autoimmune manifestation in spontaneous mouse model of lupus using anti\u2010annexin A1 antibody. Groups of lupus\u2010prone MRL\/lpr mice were treated with the anti\u2010annexin A1 monoclonal antibody, and the disease activity and survival of the animals were following up. Flow cytometry, ELISA assays, and histological and immunofluorescence kidney analyses were used to determine the levels of Annexin A1 expression, cytokines, anti\u2010dsDNA antibodies and kidney injuries. The administration of this monoclonal antibody to MRL\/lpr mice resulted in suppression of IgG anti\u2010dsDNA antibody production, modulated IL\u201010 secretion, decreased disease activity and prolonged survival compared with the control group.<\/jats:p>","DOI":"10.1111\/sji.12915","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T19:59:18Z","timestamp":1592078358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monoclonal antibody therapy that targets phospholipid\u2010binding protein delays lupus activity in MRL\/lpr mice"],"prefix":"10.1111","volume":"92","author":[{"given":"Nikolina","family":"Mihaylova","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Immunology Institute of Microbiology Bulgarian Academy of Sciences  Sofia 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