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However, the heterogeneity of bone marrow (BM)\u2010derived LMs populations remains to be understood. To investigate this and understand the impact of the macrophage niche on the properties of recruited BM\u2010derived macrophages, we used a non\u2010myeloablation BM transplantation model to label and trace BM\u2010derived LMs. Subsequently, we quantified the number of embryonic\u2010derived liver\u2010resident macrophages, BM\u2010derived LMs and total LMs in CCl<jats:sub>4<\/jats:sub> and irradiated acute liver injury mouse models, respectively. Finally, we compared the cell fate, gene expression patterns, chemokine signals, and surface markers of irradiated and CCl<jats:sub>4<\/jats:sub>\u2010treated BM\u2010derived LMs. We observed that, as compared to CCl<jats:sub>4,<\/jats:sub> radiation generated a macrophage niche by depleting embryonic\u2010derived liver\u2010resident macrophages and induced the recruitment of BM\u2010derived LMs that further settled in the liver. Irradiated and CCl<jats:sub>4<\/jats:sub>\u2010treated BM\u2010derived LMs are different with respect to their cell fates, gene expression patterns, and chemokine expression and recruitment. They also have different surface markers shortly after differentiating from their progenitors. Our findings suggest that irradiated and CCl<jats:sub>4<\/jats:sub>\u2010treated LM populations derived from the bone marrow display different patterns of gene expression and phenotypes; these differences may be due to the availability of macrophage niche.<\/jats:p>","DOI":"10.1111\/sji.12916","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T09:12:56Z","timestamp":1592039576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Irradiated and CCl<sub>4<\/sub>\u2010treated bone marrow\u2010derived liver macrophages exhibit different gene expression patterns and phenotypes"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-6875","authenticated-orcid":false,"given":"Xu","family":"Fan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) 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