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Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood\u2010borne, thymus\u2010independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4<jats:sup>+<\/jats:sup> helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level.<\/jats:p>","DOI":"10.1111\/sji.12920","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T10:49:56Z","timestamp":1593341396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Putative role of marginal zone B cells in pathophysiological processes"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-4370","authenticated-orcid":false,"given":"Dragan","family":"Marinkovic","sequence":"first","affiliation":[{"name":"Faculty of Special Education and Rehabilitation University of Belgrade Belgrade 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