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The related <jats:italic>Basidiomycota Agaricus blaz<\/jats:italic>ei Murill (AbM), <jats:italic>Hericium erinaceus<\/jats:italic> (HE), and <jats:italic>Grifola frondosa<\/jats:italic> (GF) have been shown to exert antimicrobial activity against viral agents, Gram\u2010positive and Gram\u2010negative bacteria, and parasites in vitro and in vivo. Since the mechanism is immunomodulatory and not antibiotical, the mushrooms should be active against multi\u2010drug resistant microbes as well. Moreover, since these <jats:italic>Basidiomycota<\/jats:italic> also have anti\u2010inflammatory properties, they may be suited for treatment of the severe lung inflammation that often follows COVID\u201019 infection. An AbM\u2010based mushroom extract (Andosan\u2122), also containing HE and GF, has been shown to significantly reduce bacteraemia and increase survival in mice with pneumococcal sepsis, and to improve symptoms and quality of life in IBD patients via an anti\u2010inflammatory effect. Hence, such mushroom extracts could have prophylactic or therapeutic effect against the pneumonic superinfection and severe lung inflammation that often complicates COVID\u201019 infection. Here, we review antimicrobial and anti\u2010inflammatory properties of AbM, HE and GF mushrooms, which could be used for the battle against COVID\u201019.<\/jats:p>","DOI":"10.1111\/sji.12937","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:30:50Z","timestamp":1594636250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Can medicinal mushrooms have prophylactic or therapeutic effect against COVID\u201019 and its pneumonic superinfection and complicating inflammation?"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-3436","authenticated-orcid":false,"given":"Geir","family":"Hetland","sequence":"first","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital (OUH) Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo 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