{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:45Z","timestamp":1790671545053,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the past decades, clinical and experimental evidence has demonstrated that psoriasis is an immune\u2010mediated inflammatory disease of the skin that occurs in genetically susceptible individuals. Psoriasis also shows clear autoimmune pathomechanisms, but specific cellular targets for the onset and maintenance of psoriatic lesions were not established until 2014. Since then, four psoriasis autoantigens were discovered, namely cathelicidin LL\u201037, melanocytic ADAMTSL5, lipid antigen PLA2G4D and keratin 17. Autoreactive T cells against these autoantigens were found in a number of patients with moderate\u2010to\u2010severe plaque psoriasis. Moreover, the discovery of autoantibodies against LL\u201037 and ADAMTSL5 and their strong association with psoriatic arthritis (PsA) suggest a potential role of these autoantibodies in the pathogenesis of PsA. This review discusses the current studies on psoriatic autoantigens and the associated circulating autoantibodies and their mechanisms involved in the development and maintenance of psoriatic plaques. Recent autoimmune evidence fuelled the discussion on psoriasis as an autoimmune skin disorder and has the potential to develop new treatment strategies with protective and therapeutic antigen\u2010targeted methods.<\/jats:p>","DOI":"10.1111\/sji.12945","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T10:54:57Z","timestamp":1595415297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Current knowledge on autoantigens and autoantibodies in psoriasis"],"prefix":"10.1111","volume":"92","author":[{"given":"Lisa Lynn","family":"ten Bergen","sequence":"first","affiliation":[{"name":"Broegelmann Research Laboratory Department of Clinical Science University of Bergen Bergen Norway"},{"name":"Vrije Universiteit Amsterdam Amsterdam The 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