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The immune evasion strategies that a filarial parasite usually follows are chiefly initiated with the communication between the invaded parasites and parasite\u2010derived molecules, with the Toll\u2010like receptors (TLRs) present on the surface of the antigen\u2010presenting cells (APCs). Classically, the filarial parasites interact with the DCs resulting in lowering of CD4<jats:sup>+<\/jats:sup> T\u2010cell responses. These CD4<jats:sup>+<\/jats:sup> T\u2010cell responses are the key players behind the immune\u2010mediated pathologies associated with LF. In chronic stage, the canonical pro\u2010inflammatory immune responses are shifted towards an anti\u2010inflammatory subtype, which is favouring the parasite survivability within the host. 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