{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:59Z","timestamp":1753879439577,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","award":["SKGJ\u2010MED\u2010017"],"award-info":[{"award-number":["SKGJ\u2010MED\u2010017"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010type lectin\u2010like CD161, a class II transmembrane protein, is a surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was expressed more frequently on gluten\u2010reactive CD4\u00a0+\u00a0T cells compared to other memory CD4\u00a0+\u00a0T cells isolated from the same tissue compartment. CD161 is a putative co\u2010signalling molecule that was proposed to act as co\u2010stimulatory receptor in the context of signalling through TCR, but contradicting results were published. In order to understand the role of CD161 in gluten\u2010reactive CD4\u00a0+\u00a0T cells, we combined T cell stimulation assays or T cell proliferation assays with ligation of CD161 and intracellular cytokine staining. We found that CD161 ligation provided neither co\u2010stimulatory nor co\u2010inhibitory signals to modulate proliferation and IFN\u2010\u03b3 or IL\u201021 production by gluten\u2010reactive CD4\u00a0+\u00a0T cell clones. Thus, we suggest that CD161 does not function as a co\u2010signalling receptor in the context of gluten\u2010reactive CD4\u00a0+\u00a0T cells.<\/jats:p>","DOI":"10.1111\/sji.13016","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T16:36:12Z","timestamp":1608827772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["C\u2010type lectin\u2010like CD161 is not a co\u2010signalling receptor in gluten\u2010reactive CD4\u00a0+\u00a0T cells"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-5064","authenticated-orcid":false,"given":"\u0141ukasz","family":"Wyro\u017cemski","sequence":"first","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Immunology University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Immunology University of Oslo Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo\u2010Wang","family":"Qiao","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Immunology University of Oslo Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0054-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0985-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601693"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614540154"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.6.766"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.36"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.5886"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0403-9"},{"issue":"6","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.4049\/jimmunol.153.6.2417","article-title":"Human NKR\u2010P1A. 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