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CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate\u2010like T cells and marker of IL\u201017\u2010producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co\u2010signalling receptor that influence T\u2010cell receptor\u2010dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T\u2010cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. 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