{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:58Z","timestamp":1753879258633,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoadsorption apheresis (IA) or intravenous immunoglobulin (IVIg) is used to treat exacerbation of myasthenia gravis (MG). This study aimed to compare the efficacy and safety between IA and IVIg for MG patients with anti\u2010acetylcholine receptor (AChR) antibodies. We retrospectively studied 19 AChR antibody\u2010positive generalized MG patients who underwent IA (n\u00a0=\u00a09) or IVIg treatment (n\u00a0=\u00a010). We reviewed the MG activities of daily living profile (MG\u2010ADL) scores at baseline, 1 and 3\u00a0months after the treatment. Adverse events during the treatment period were also reviewed. The MG\u2010ADL scores showed significantly greater improvement from the baseline in the IA group than in the IVIg group (1\u00a0month: \u22127 vs \u22123, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.035; 3\u00a0months \u22129 vs \u22122.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016). An adverse event that led to the discontinuation of the treatment was observed in only one patient in the IVIg group (anaphylactic reaction). Our data suggest that the IA treatment is safe and more efficacious than the IVIg treatment for aggravation of anti\u2010AChR\u2010positive MG. Larger prospective studies are required to confirm the finding.<\/jats:p>","DOI":"10.1111\/sji.13122","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T10:39:40Z","timestamp":1637318380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunoadsorption apheresis versus intravenous immunoglobulin therapy for exacerbation of myasthenia gravis"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-3857","authenticated-orcid":false,"given":"Manato","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1863","authenticated-orcid":false,"given":"Akiyuki","family":"Uzawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-6949","authenticated-orcid":false,"given":"Yukiko","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Neurology Japanese Red Cross Narita Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-5419","authenticated-orcid":false,"given":"Yuta","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Neurology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Akamine","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-8578","authenticated-orcid":false,"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03019.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr284"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410615"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821e5505"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602678"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.338"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20317"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139889201500511"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2009.00751.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1487"},{"key":"e_1_2_10_14_1","first-page":"153","article-title":"Myasthenia gravis: recommendations for clinical research standards. task force of the medical scientific advisory board of the myasthenia gravis foundation of America","volume":"55","author":"Jaretzki A","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285616637046"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14479"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.629"},{"key":"e_1_2_10_19_1","first-page":"CD002277","article-title":"Intravenous immunoglobulin for myasthenia gravis","volume":"12","author":"Gajdos P","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25397"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.13122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sji.13122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.13122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:03:46Z","timestamp":1693195426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.13122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/sji.13122"],"URL":"https:\/\/doi.org\/10.1111\/sji.13122","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"type":"print","value":"0300-9475"},{"type":"electronic","value":"1365-3083"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"2021-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13122"}}