{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:44:10Z","timestamp":1753879450663,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14CC0001","NNF17OC0027594"],"award-info":[{"award-number":["NNF14CC0001","NNF17OC0027594"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF 18002"],"award-info":[{"award-number":["LF 18002"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial clustering of the skin disease primary hyperhidrosis suggests a genetic component to the disease. The human leucocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No study has investigated whether the HLA genes are involved in the pathogenesis of hyperhidrosis. We, therefore, compared HLA alleles in individuals with and without hyperhidrosis in this study of 65\u00a0000 blood donors. In this retrospective cohort study, we retrieved information on individuals with and without hyperhidrosis using self\u2010reported questionnaires, the Danish National Patient Registry and the Danish National Prescription Registry on participants recruited to the Danish Blood Donor Study between 2010 and 2019. Association tests using logistic regression were conducted for each HLA allele corrected for sex, age, body mass index, smoking and principal components. Overall, 145 of 65\u00a0795 (0.2%) participants had hospital diagnosed hyperhidrosis. Similarly, 1379 of 15\u00a0530 (8.9%) participants had moderate\u2010severe self\u2010reported hyperhidrosis, of whom 447 (2.9%) had severe self\u2010reported hyperhidrosis. Altogether, 28 participants had both hospital diagnosed and moderate\u2010severe self\u2010reported hyperhidrosis. Severe self\u2010reported hyperhidrosis was associated with HLA\u2010A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32\u2010136.70; n\u00a0=\u00a07; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Moderate\u2010severe self\u2010reported hyperhidrosis and hospital diagnosed hyperhidrosis were not associated with any HLA. The association between hyperhidrosis and HLA\u2010A*80:01 was based on a very small number of cases and not replicated in other patient subsets, and therefore likely a chance finding. Thus, this study suggests that genes other than the HLA are involved in the pathogenesis of hyperhidrosis.<\/jats:p>","DOI":"10.1111\/sji.13150","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:53:49Z","timestamp":1645779229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-2248","authenticated-orcid":false,"given":"Mattias","family":"AS Henning","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer E.","family":"Hother","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Banasik","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina S.","family":"Ibler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse","family":"Rye Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-9643","authenticated-orcid":false,"given":"Kaspar R.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"State Serum Institute  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Hansen","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Neurology Danish Headache Center Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrine A.","family":"Kaspersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"},{"name":"Danish Big Data Centre for Environment and Health (BERTHA) Aarhus University  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betina S.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne G.","family":"S\u00e6kmose","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor B. 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