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The complement system protects against pathogens and plays essential roles in homeostasis and development. The influence of the complement system in CVID is not established. We investigated CVID patients and healthy individuals for plasma levels of the complement proteins: MASP\u20101, MASP\u20102, MASP\u20103, MAp19 and MAp44. We also tested other patients with symptoms similar to the CVID patients. CVID patients had lower average MASP\u20102 and MAp44 levels than healthy individuals (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01); the MASP\u20102 level was 0.73\u2010fold lower, and the MAp44 level was 0.87\u2010fold lower. This was not observed in the other patient cohorts studied. Our findings in this exploratory study provide new insights into CVID and introduce a complement perspective for future investigations into the underlying mechanisms of the disease.<\/jats:p>","DOI":"10.1111\/sji.13196","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T08:09:01Z","timestamp":1654675741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low levels of the innate immune system proteins <scp>MASP<\/scp>\u20102 and <scp>MAp44<\/scp> in patients with common variable immunodeficiency"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-2192","authenticated-orcid":false,"given":"Clara Elb\u00e6k","family":"Mistegaard","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical 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