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Here, we show that glycoprotein 2 (GP2), a GPI\u2010anchored protein and receptor for bacterial type\u2010I fimbriae, is selectively expressed by CD103<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> cDC in the murine small intestine (SI). GP2 expression was induced on CD103<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> cDC within the SI\u2010LP and was regulated by IRF4, TGF\u03b2R1\u2010 and retinoic acid signalling. Mice selectively lacking <jats:italic>Gp2<\/jats:italic> on CD103<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> cDC (<jats:italic>huLang\u2010Cre<\/jats:italic>.<jats:italic>gp2<\/jats:italic><jats:sup><jats:italic>fl\/fl<\/jats:italic><\/jats:sup> mice) had normal numbers and proportions of innate and adaptive immune cells in the SI\u2010LP suggesting that GP2 expression by CD103<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> cDC is not required for intestinal immune homoeostasis.<\/jats:p>","DOI":"10.1111\/sji.13219","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T06:43:09Z","timestamp":1664347389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification and characterization of murine glycoprotein 2\u2010expressing intestinal dendritic cells"],"prefix":"10.1111","volume":"96","author":[{"given":"Katarzyna 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