{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:03Z","timestamp":1787016003315,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Therapeutic application of vaccines to endometrial carcinoma (EC) remains uncertain. In this study, we aimed to identify potential tumour antigens for use in the development of an anti\u2010tumour mRNA vaccine and clarify immune subtypes and their characteristics for immunotherapeutic application in heterogeneous EC by integrating multi\u2010omics data. Importantly, four potential tumour antigen candidates\u2014\n                    <jats:italic>PGR<\/jats:italic>\n                    ,\n                    <jats:italic>RBPJ<\/jats:italic>\n                    ,\n                    <jats:italic>PARVG<\/jats:italic>\n                    and\n                    <jats:italic>MSX1<\/jats:italic>\n                    \u2014were identified and significantly correlated with better overall survival, disease\u2010free survival and distinct antigen\u2010presenting cell infiltration in EC. In addition, two different immune subtypes by consensus clustering analysis of the immune\u2010related genes were identified. Patients with C2 immunophenotypes exhibited superior survival outcomes and \u2018hot\u2019 immunoreactivity and harboured higher microsatellite instability scores and tumoral mutation burden but lower copy\u2010number variation burden. Furthermore, the distinct expression of immunogenic cell death modulators and differential microenvironmental characteristics of immune\u2010cell infiltration were also revealed between C1 and C2 immune\u2010subtype tumours. Enrichment analysis of the co\u2010expression of immune\u2010related genes showed enrichment in immune response, immune cell\u2010mediated immunity and antigen processing pathways. These results indicated that these identified tumour antigens can be used for developing antitumour mRNA vaccines, and tumours with C2 immunophenotypic characteristics demonstrated sensitivity and susceptibility to immunotherapy in EC.\n                  <\/jats:p>","DOI":"10.1111\/sji.13250","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T01:46:25Z","timestamp":1672191985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of tumour antigens and immune subtypes in the development of an anti\u2010cancer vaccine for endometrial carcinoma"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5859","authenticated-orcid":false,"given":"Jianyang","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease the Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5335-5433","authenticated-orcid":false,"given":"Hong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease the Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21654"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21561"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE12113"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30445-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YGYNO.2019.11.035"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAN6733"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAONCOL.2015.2151"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2019.03023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2655"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YGYNO.2020.01.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12943-021-01335-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12943-021-01348-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134915"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0412"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2018.02.060"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0327-7_16"},{"key":"e_1_2_10_19_1","unstructured":"YoshiharaK KimH VerhaakRGW.Estimate: estimate of stromal and immune cells in malignant tumor tissues from expression data. 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