{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:09:22Z","timestamp":1791922162989,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306575\/2019\u20101"],"award-info":[{"award-number":["306575\/2019\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/203.192\/2017"],"award-info":[{"award-number":["E\u201026\/203.192\/2017"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between psoriasis severity and psychological stress has been described in several studies. However, the mechanism by which chronic stress exacerbates psoriasis is not completely understood. This study aimed at investigating whether chronic psychological stress can aggravate psoriasis\u2010like skin inflammation. Mice were subjected to a restraint stress model and topically treated with imiquimod (IMQ). Differentiated human keratinocytes were treated with high epinephrine levels and IMQ in vitro. Stress aggravated macroscopic features and the increase in epidermal thickness induced by IMQ in mouse skin. The increase in NF\u2010\u03baB and IL\u201017A expression induced by IMQ was potentiated by chronic stress in mouse skin. The skin of stressed mice treated with IMQ showed higher levels of \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptors (\u03b2<jats:sub>2<\/jats:sub>\u2010AR). In human keratinocytes, high epinephrine levels exacerbated the increase in the levels of \u03b2<jats:sub>2<\/jats:sub>\u2010AR and IL\u201017A induced by IMQ. \u03b2\u2010AR antagonist reversed the effects of chronic stress in IMQ\u2010induced inflammation both in vivo and in vitro. In conclusion, stress\u2010stimulated overactivation of the \u03b2<jats:sub>2<\/jats:sub>\u2010AR and NF\u2010\u03baB pathways potentiates a Th1\/Th17 profile leading to an exacerbation of psoriasis.<\/jats:p>","DOI":"10.1111\/sji.13258","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T06:38:56Z","timestamp":1675406336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chronic psychological stress aggravates psoriasis\u2010like skin inflammation via overactivation of \u03b2<sub>2<\/sub>\u2010adrenoceptor and nuclear factor kappa B pathways"],"prefix":"10.1111","volume":"97","author":[{"given":"Aline","family":"Donato\u2010Trancoso","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Rio de Janeiro State University  Rio de Janeiro 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