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DNases may disrupt NETs by degrading their content of DNA, and a balance has been reported between NETs and DNases. Because of this and since the inflammatory marker NETs may be used as a confirmatory test in diagnosing VITT, it is of interest to monitor levels of DNase in patients with increased NETs levels. The current novel rapid DNase ELISA was tested in blood samples of patients with known increased levels of NETs with or without VITT after ChAdOx1 nCoV\u201019 vaccination. DNase levels in VITT patients were significantly increased compared with normal unvaccinated blood donors and compared with patients with post\u2010vaccination symptoms but not VITT. However, since EDTA was found to inhibit DNase, serum and not EDTA\u2010plasma samples should be applied for DNase testing. The novel DNase assay may serve as a supplementary test to the NETs test when analysing samples from patients with suspected increased NETs levels.<\/jats:p>","DOI":"10.1111\/sji.13274","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T13:28:50Z","timestamp":1682688530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>DNase<\/scp> analysed by a novel competitive assay in patients with complications after <scp>ChAdOx1 nCoV<\/scp>\u201019 vaccination and in normal unvaccinated blood donors"],"prefix":"10.1111","volume":"98","author":[{"given":"Magne Kristoffer","family":"Fagerhol","sequence":"first","affiliation":[{"name":"Department of Immunology Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Haagenrud","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of 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