{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:34:48Z","timestamp":1788305688709,"version":"build-2803163510"},"reference-count":120,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Group 2 innate lymphoid cells (ILC2s) are a type of innate immune cells that produce a large amount of IL\u20105 and IL\u201013 and two cytokines that are crucial for various processes such as allergic airway inflammation, tissue repair and tissue homeostasis. It is known that damaged epithelial\u2010derived alarmins, such as IL\u201033, IL\u201025 and thymic stromal lymphopoietin (TSLP), are the predominant ILC2 activators that mediate the production of type 2 cytokines. In recent years, abundant studies have found that many factors can regulate ILC2 development and function. Hormones synthesized by the body's endocrine glands or cells play an important role in immune response. Notably, ILC2s express hormone receptors and their proliferation and function can be modulated by multiple hormones during allergic airway inflammation. Here, we summarize the effects of multiple hormones on ILC2\u2010driven allergic airway inflammation and discuss the underlying mechanisms and potential therapeutic significance.<\/jats:p>","DOI":"10.1111\/sji.13357","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T07:24:25Z","timestamp":1705735465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of hormones in <scp>ILC2<\/scp>\u2010driven allergic airway inflammation"],"prefix":"10.1111","volume":"99","author":[{"given":"Zhongling","family":"Dai","sequence":"first","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2761-8634","authenticated-orcid":false,"given":"Zhande","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WeiXiang","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-5520","authenticated-orcid":false,"given":"Aihua","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China  Hengyang China"},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.05.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.118"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0210-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12526"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33005-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.06.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3489"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13604"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112073"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0164-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05297-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05395-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00942-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400951"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.04.101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-023-00272-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934509"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00086.2006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.1800008"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.110"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161807"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.09.019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.029"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14491"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.1062412"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00483-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02649-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0021-75572007000700007"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_98"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17023"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13438"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3675"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69288-X"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0099OC"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.037"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174732"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.032"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201909-1722OC"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd3489"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.016"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC03237B"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.09.011"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101029"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.050"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00501"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15541"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108313"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201410-1793OC"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600275"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.038"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.056"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900745"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01852-3"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.069"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901544"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13831"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.022"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068845"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.09.037"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08449-x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13107"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.130"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.08.021"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6056373"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02331-0"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-00982-6"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.009"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0649-0"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061321"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.030"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0415OC"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238990"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191054"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4764751"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.016"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8712-1"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14879"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1971973"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160920195"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1314078"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.043"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.053"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.06.421"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12050755"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211001"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1366"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211985"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121780"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9248479"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.743187"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4176082"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0229"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.03.028"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835953"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13861"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.2.7"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.09.001"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-45"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.757967"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00516-9"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.007"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75468"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1062977"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.017"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.02.011"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.002"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200311000-00019"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12549"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001274"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.03.005"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13008"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2020.03.012"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00424-2"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4829"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03830-7"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00704-5"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.13357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T03:51:11Z","timestamp":1713153071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.13357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":120,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/sji.13357"],"URL":"https:\/\/doi.org\/10.1111\/sji.13357","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"assertion":[{"value":"2023-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13357"}}