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Here, we report the results of a systematic analysis of MAIT cells in treatment\u2010na\u00efve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L vs. 0.05\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T\u2010cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B\u2010cell non\u2010Hodgkin lymphomas, otherwise not specified, diffuse large B\u2010cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD\u20101 (average values, 51.7% vs. 6.7%), HLA\u2010DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated\/exhausted phenotype.<\/jats:p>","DOI":"10.1111\/sji.13364","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T04:10:35Z","timestamp":1709698235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic analysis of mucosal\u2010associated invariant T cells in haematological malignancies"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-2157","authenticated-orcid":false,"given":"Barbora","family":"Bacova","sequence":"first","affiliation":[{"name":"Laboratory of Haematology\u2014Central Laboratories University Hospital Kralovske Vinohrady  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Cierny","sequence":"additional","affiliation":[{"name":"Department of Haematology, 3rd Faculty of Medicine Charles University and 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