{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T04:07:26Z","timestamp":1754021246496,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep\u20102 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti\u2010Golgi antibodies. We examined 4.5\u2009years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of which 224 patients (0.15%) exhibited anti\u2010Golgi antibody staining. In total, 39.4% of diagnosed patients had autoimmune diseases (AIDs). Of the AIDs, 26 (46.4%) were rheumatoid arthritis (RA). This is a very high rate and another remarkable point is that 17 (65.3%) of these patients had seronegative RA. High\u2010titre results (1\u2009\u2265\u20091\/320) were more common in patients with AID. Anti\u2010Ro52 was prevalent in 50% of extractable nuclear antigen (ENA)\u2010positive patients, making it a remarkable finding. The majority of individuals with high\u2010titre anti\u2010Golgi antibodies had AID, particularly RA. The majority of these patients also tested negative for anti\u2010cyclic citrullinated peptide (anti\u2010CCP) and rheumatoid factor (RF). Finally, high\u2010titre anti\u2010Golgi antibodies may be an important serologic marker for seronegative RA in the Turkish population.<\/jats:p>","DOI":"10.1111\/sji.13369","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T05:05:40Z","timestamp":1712120740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated levels of anti\u2010Golgi antibodies: An early sign of seronegative rheumatoid arthritis"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5293-0803","authenticated-orcid":false,"given":"Emrah","family":"Salman","sequence":"first","affiliation":[{"name":"Department of Immunology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-2556","authenticated-orcid":false,"given":"Bedia","family":"Din\u00e7","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12151972"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"579","article-title":"Anti\u2010golgi complex autoantibodies in a patient with Sj\u00f6gren syndrome and lymphoma","volume":"49","author":"Rodr\u00edguez JL","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.06.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.3832"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1035"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp14X681601"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-016-0075-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316640920"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126391"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01353.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.10.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0362"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809098799"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.132.6.2904"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050115"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.10.986a"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmab046"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00165"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13136"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7098"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182117"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25765"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1992.tb03140.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/go7g26"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar422"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13133"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.13369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T07:10:06Z","timestamp":1718003406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.13369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/sji.13369"],"URL":"https:\/\/doi.org\/10.1111\/sji.13369","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"type":"print","value":"0300-9475"},{"type":"electronic","value":"1365-3083"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13369"}}