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The association between regulatory T cells (Tregs) and AIN has been described, and in this study, we investigated three Treg\u2010associated genes, <jats:italic>IL\u20102<\/jats:italic>, <jats:italic>IL\u201010<\/jats:italic> and <jats:italic>FOXP3<\/jats:italic>. The frequencies of three single nucleotide polymorphisms (SNPs) in <jats:italic>IL\u20102<\/jats:italic> \u2212330T&gt;G (rs2069762), +114G&gt;T (rs2069763) and IVS3\u2010116 A&gt;G (rs2069772), four SNPs in <jats:italic>IL\u201010<\/jats:italic> \u22123575T&gt;A (rs1800890), \u22121082G&gt;A (rs1800896), \u2212819 C&gt;T (rs1800871) and \u2212592 C&gt;A (rs1800872) and three SNPs in <jats:italic>FOXP3<\/jats:italic> \u20133499 A&gt;G (rs3761547), \u22123279 C&gt;A (rs3761548) and \u2212924 A&gt;G (rs2232365) were compared between 166 Danish AIN patients and 358 healthy controls. Disease association was observed for <jats:italic>IL\u20102<\/jats:italic> IVS3\u2010116 GG (<jats:italic>p<\/jats:italic>\u2009=\u20090.0081, OR\u2009=\u20090.35 [0.15\u20130.80]), <jats:italic>IL\u201010<\/jats:italic> \u2212<jats:italic>3<\/jats:italic>575 TT (<jats:italic>p<\/jats:italic>\u2009=\u20090.0078, OR\u2009=\u20091.71 [1.16\u20132.54]) and <jats:italic>IL\u201010<\/jats:italic> \u2212<jats:italic>1<\/jats:italic>082 AA (<jats:italic>p<\/jats:italic>\u2009=\u20090.014, OR\u2009=\u20091.76 [1.14\u20132.72]) in all patients and <jats:italic>FOXP3 \u2013<\/jats:italic>924 (<jats:italic>p<\/jats:italic>\u2009=\u20090.0005, A OR\u2009=\u20090.41 [0.25\u20130.68] and G OR\u2009=\u20092.42 [1.46\u20134.01]) in male patients. None of the associations were linked to antibody specificity. Disease\u2010associated haplotypes were observed in <jats:italic>IL\u20102<\/jats:italic> and <jats:italic>FOXP3. IL\u20102<\/jats:italic> \u2212330T\/+114\u2009T\/IVS3\u2010116A was associated with anti\u2010Fc\u03b3RIIIb\u2010positive patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.012, OR\u2009=\u20092.07 [1.18\u20133.62]). <jats:italic>FOXP3<\/jats:italic> \u20133499A\/\u20133279C\/\u2212924A was associated with anti\u2010HNA\u20101a\u2010positive male patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.016, OR\u2009=\u20090.41 [0.20\u20130.83]), and ACG was associated with female patients, both in the combined group (<jats:italic>p<\/jats:italic>\u2009=\u20090.006, OR\u2009=\u2009NA) and the anti\u2010Fc\u03b3RIIIb\u2010positive group (<jats:italic>p<\/jats:italic>\u2009=\u20090.002, OR\u2009=\u2009NA). We conclude that our findings reveal a correlation between SNP in Treg\u2010associated genes and AIN, indicating that AIN could be driven by dysfunction of immune homeostatic\u2010evolving Tregs.<\/jats:p>","DOI":"10.1111\/sji.13374","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T03:54:10Z","timestamp":1715831650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic polymorphisms in <i>IL\u20102<\/i>, <i>IL\u201010<\/i> and <i>FOXP3<\/i> are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-8291","authenticated-orcid":false,"given":"Kirstine","family":"Kl\u00f8ve\u2010Mogensen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Nicole","family":"Masmas","sequence":"additional","affiliation":[{"name":"Pediatric Hematopoietic Stem Cell Transplantation and Immunodeficiency, Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Hematology Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Friis","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Section of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescence Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Department of Medicine Huddinge Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-626X","authenticated-orcid":false,"given":"Petter","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Department of Medicine Huddinge Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aarhus 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