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In the present study, the potential roles of Fbxw7 in osteomyelitis were explored. The mRNA level of Fbxw7 was measured in bone marrow cells from patients with osteomyelitis and <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S. aureus<\/jats:italic>)\u2010infected macrophages. The conditional knockout mice with Fbxw7 deficiency in myeloid cells were generated. The expression of interleukin (IL)\u20106, IL\u201023a and nitric oxide synthase 2 (Nos2) was measured in <jats:italic>S. aureus<\/jats:italic>\u2010infected Fbxw7\u2010deficient bone marrow\u2010derived macrophages (BMDMs). The body weight loss, bacterial burden, bone loss and formation and serum level of IL\u20106, IL\u201023 and TNF\u2010\u03b1 were measured in <jats:italic>S. aureus<\/jats:italic>\u2010infected Fbxw7 conditional KO mice. The interacting partners of Fbxw7 were predicted using STRING and the interaction were tested. Elevated expression of Fbxw7 was observed in bone marrow cells from patients with osteomyelitis and in <jats:italic>S. aureus<\/jats:italic>\u2010infected macrophages. The expression of IL\u20106, IL\u201023a and Nos2 was remarkably suppressed in <jats:italic>S. aureus<\/jats:italic>\u2010infected Fbxw7\u2010deficient BMDMs. Fbxw7 conditional knockout mice had less body weight loss, higher bacterial burden, less bone loss and formation and decreased serum level of cytokines. Fbxw7 interacted with MYB. <jats:italic>S. aureus<\/jats:italic>\u2010infected Fbxw7\u2010deficient BMDMs had higher level of MYB and less ubiquitination of MYB. Fbxw7 promotes osteomyelitis symptoms by regulating ubiquitination and stability of MYB.<\/jats:p>","DOI":"10.1111\/sji.13414","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T04:43:16Z","timestamp":1730522596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["F\u2010Box and <scp>WD<\/scp> repeat domain containing 7 induces infectious osteomyelitis by regulating <scp>MYB<\/scp> stability and ubiquitination"],"prefix":"10.1111","volume":"100","author":[{"given":"Yongbo","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Haikou Orthopedic and Diabetes Hospital of Shanghai Sixth People's Hospital  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The First Hospital of China Medical University  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