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The aim of this study was to evaluate the impact of first\u2010line disease\u2010modifying drugs used in treatment of RRMS on expression of the STAT pathway and T\u2010cell\u2010related genes in the blood and on serum concentrations of sgp130 and TGF\u2010\u03b21 in women, as well as on the level of phosphorylated STAT3 and STAT5 proteins in T cells of untreated patients and heathy controls. Expression of <jats:italic>STAT1<\/jats:italic>, <jats:italic>STAT3<\/jats:italic>, <jats:italic>STAT5A<\/jats:italic>, <jats:italic>STAT5B<\/jats:italic>, <jats:italic>SOCS1<\/jats:italic>, <jats:italic>SOCS3<\/jats:italic>, <jats:italic>FOXP3<\/jats:italic>, <jats:italic>IKZF2<\/jats:italic>, <jats:italic>RORC<\/jats:italic> and <jats:italic>ICOS<\/jats:italic> genes in the blood of untreated RRMS patients, in the blood of patients treated with interferon\u2010\u03b2, glatiramer acetate, dimethyl fumarate or teriflunomide and in the blood of healthy controls was evaluated using droplet digital PCR. Serum concentrations of sgp130 and TGF\u2010\u03b21 were evaluated by ELISA. Phosphorylated STAT3 and STAT5 protein levels in T cells were evaluated by flow cytometry. <jats:italic>STAT3<\/jats:italic> gene expression was significantly higher in untreated patients than in healthy control, but the level of phosphorylated STAT3 in T cells was significantly lower. Patients treated with interferon\u2010\u03b2 or dimethyl fumarate had significantly lower <jats:italic>STAT3<\/jats:italic> gene expression. Patients treated with teriflunomide had higher <jats:italic>STAT1<\/jats:italic> gene expression, than untreated patients. Patients treated with dimethyl fumarate also had significantly lower <jats:italic>RORC<\/jats:italic> gene expression than untreated patients. The study shows the impact of drugs used in first\u2010line treatment of relapsing\u2010remitting multiple sclerosis on expression of <jats:italic>STAT<\/jats:italic> and T\u2010cell\u2010related genes.<\/jats:p>","DOI":"10.1111\/sji.13424","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T11:30:48Z","timestamp":1731670248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of <scp>STAT<\/scp>\u2010 and T\u2010cell\u2010related genes in women with first\u2010line treatment of relapsing\u2010remitting multiple sclerosis"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-3088","authenticated-orcid":false,"given":"Ludmi\u0142a","family":"Szewczak","sequence":"first","affiliation":[{"name":"Laboratory of Parasitology General Karol Kaczkowski Military Institute of Hygiene and Epidemiology  Warsaw Poland"},{"name":"Department of 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