{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:49:13Z","timestamp":1769824153442,"version":"3.49.0"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vitronectin (Vn) is a complement regulatory component found in humans and a variety of animals. It can inhibit the formation of membrane attack complexes in the complement system. Studies have shown that a variety of pathogenic microorganisms, including <jats:styled-content style=\"fixed-case\"><jats:italic>Yersinia pestis<\/jats:italic><\/jats:styled-content>, dengue viruses, <jats:italic>Plasmodium<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>Candida albicans<\/jats:italic><\/jats:styled-content>, may recruit Vn on the surface of pathogens and inhibit the killing effect of the complement system in the host. After entering the body, pathogenic microorganisms may attach to and infect target cells through multiple pathogenic mechanisms. Meanwhile, the body will attack the invading pathogenic microorganisms through its own immune system. However, the immune escape of pathogens will make the host's immune system difficult to respond effectively, thus causing the aggravation of the disease. Therefore, the study of immune escape is of great significance for the treatment, prevention and control of infectious diseases and tumours. In this paper, the mechanism of vitronectin (one of the complement regulatory factors)\u2010mediated immune escape of pathogens is reviewed from multiple aspects.<\/jats:p>","DOI":"10.1111\/sji.70019","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:40:08Z","timestamp":1744360808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Advances on Molecular Mechanisms of Complement Regulatory Factor Vitronectin\u2010Mediated Immune Escape of Pathogens"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5395-7364","authenticated-orcid":false,"given":"Tong","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9341-3671","authenticated-orcid":false,"given":"Yujie","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9611-8552","authenticated-orcid":false,"given":"Yuelin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine of Southwest University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5510-7402","authenticated-orcid":false,"given":"Wenman","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine of Southwest University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5507-3261","authenticated-orcid":false,"given":"Yunzhi","family":"Fa","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences Academy of Military Sciences of Chinese People's Liberation Army  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.13.4003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.2010.07373.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.1996.d01\u2010833.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200625"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2005.01324.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101276590"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101642687"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.15.2189"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.6.1145"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104439(03)00059\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010009\u20100834\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201023194\u20109"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.04.025"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.5.1379\u20101381.1993"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0205065"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01065\u201009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2620"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147709"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.03.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.430"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137630"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/596211"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803226"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14\u201006\u20100561"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.443507"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00819\u201008"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1597\u20101611.2006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.2010.07066.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.54.3.689\u2010694.1986"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.8.1878\u20101883.1987"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.05.004"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.05.233"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.401"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000179"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.13.2669"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.069"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000911"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.1.70\u201075.1991"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3340133"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(98)00144\u20106"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0934\u20108840(11)80910\u20102"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.10.5770\u20105778.2002"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26145\u20100"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.1992.tb05904.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.1994.tb00470.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.1.20"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.4.617\u2010629.2002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.1999.tb13630.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.10.007"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.2008.01128.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12243"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179544"},{"issue":"288","key":"e_1_2_11_54_1","first-page":"179","article-title":"Comparative Studies on Binding of Vitronectin and Fibronectin to Groups A and C Streptococci","volume":"71","author":"Kostrzynska M.","year":"1992","journal-title":"Microbios"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(97)00330\u2010x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02844\u201014"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085069\u2010w"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.2002.tb00627.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.035600"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002849900467"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20101135(99)00037\u20101"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.01.017"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37141999000100003"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002840010230"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26527\u20100"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0934\u20108840(11)80396\u20108"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002849900135"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284\u2010002\u20103879\u20102"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00912\u201016"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20109071(199801)54:1<44::aid\u2010jmv7>3.0.co;2\u2010p"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236763"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i36.5659"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010015\u20100531\u20104"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01636\u201013"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010015\u20100600\u20108"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12164"},{"key":"e_1_2_11_77_1","first-page":"88","article-title":"Dynamics of Neisseria meningitidis Interactions with Human Cellular Barriers and Immune Effectors","volume":"18","author":"Griffiths N. J.","year":"2009","journal-title":"VacciMonitor"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.101474"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713\u201045\u20104\u2010804"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00061"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010066"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:13:11Z","timestamp":1748351591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/sji.70019"],"URL":"https:\/\/doi.org\/10.1111\/sji.70019","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70019"}}