{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:38Z","timestamp":1753879298103,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23FC1009"],"award-info":[{"award-number":["23FC1009"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Muscle\u2010specific tyrosine kinase antibody\u2010positive myasthenia gravis (MuSKMG) is a rare subtype of MG that is often more refractory to immune treatment than acetylcholine receptor (AChR) antibody\u2010positive MG. Therefore, novel therapeutic strategies are needed. We previously developed AChR\u2010Fc, an Fc fusion protein that neutralises pathogenic autoantibodies and suppresses pathogenic B cells while preserving normal immunity, as a potential treatment for AChR antibody\u2010positive MG. Subsequently, we conducted preliminary experiments on MuSK\u2010Fc, a fusion protein targeting MuSKMG, using patient serum samples. This study examined whether MuSK\u2010Fc binds to MuSK antibodies and inhibits MuSK antibody binding to MuSK. We found that MuSK\u2010Fc specifically binds to MuSK antibodies and prevents their interaction with MuSK. These findings indicate that MuSK\u2010Fc may neutralise pathogenic antibodies and suppress disease activity in MuSKMG.<\/jats:p>","DOI":"10.1111\/sji.70033","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T07:04:38Z","timestamp":1748070278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Fusion Protein <scp>MuSK<\/scp>\u2010Fc Functions as a Decoy to Block the Binding of Anti\u2010<scp>MuSK<\/scp> Antibodies to <scp>MuSK<\/scp>"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1863","authenticated-orcid":false,"given":"Akiyuki","family":"Uzawa","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Chiba University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Akamine","sequence":"additional","affiliation":[{"name":"Department of Neurology, 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